Propose a hypothesis to explain how self-reactive B cells are ide...

Question

Propose a hypothesis to explain how self-reactive B cells are identified and eliminated during maturation.

Accepted Answer

Hi everyone. Let's look at the next problem identify which mechanism allows the replicating B cells to adjust their receptors in such a way that they can bind to the antigens better when we look through our answer. Let's look through our answer choices here. Choice A says somatic hyper mutation. Well this is what we're looking for here in somatic hyper mutation um after the B cell binds to an antigen and therefore is signaled to begin to divide and proliferate. During that division process the very gene for the variable regions of those B cells is subject to a very high rate of mutation. And so that generates a bunch of varieties of B cell slightly varying by you know, a base pair. And some of those varieties may bind better to antigen than the original B cell. Then the B cell that binds better. The new variety will replicate itself so therefore automatically selecting for mutations that bind better to antigens. So that whole process of somatic hyper mutation is a mechanism that allows those B cells to adjust their receptors. So that's the answer we're looking for. But let's just walk through the other choice is to understand why they're not correct choice B says antigen presentation. Well that's when the antigen molecules are presented on the surface of an immune cell By the MHC two proteins. So that's their little uh flag system signal system where those MHC two proteins present those antigens molecules sort of as a little signal saying hey foreign cell here but not the process for adjusting receptors of the cells. So not our answer. Choice C. Is colonial selection. Well, Clonal selection is the process of producing B and T cells in response to a foreign antigen. So that's not the description of what we're looking for here. It's not a process of adjustment. So not answer C. And finally choice D. Optimization. And that's the process where pathogens are tagged by option in for destruction bye fija sites. So part of that immune system but not the process of adjusting B cell receptors. So not our answer. So again. Which mechanism allows the replicating B cells to adjust their receptors to bind to antigens? Better. That's choice A somatic hyper mutation. See you in the next video.

Propose a hypothesis to explain how self-reactive B cells are identified and eliminated during maturation.

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