Question

Why are most recombinant human proteins produced in animal or plant hosts instead of bacterial host cells?

Accepted Answer

Hello everyone and welcome to today's video. So that these advantages in using bacterial hosts to synthesize eukaryotic proteins is that we'll remember that bacteria is a type of bacteria and bacteria are very different from them. So keep that in mind as we solve the problem, we have a first, they often form inclusion bodies. Well, this is true for bacteria. However, how is this going to affect the eukaryotic protein is going to affect the sustainability of the protein with decreased cell viability. The protein won't be able to exist in environments that it would usually be able to. So this is definitely going to be a disadvantage that it brings for the eukaryotic protein. So we're going to not cancel it out. Then we have they cannot perform post translational modifications on eukaryotic proteins. Well, remember that karate proteins are in fact subject to post translational modifications are used to form, for example, like our proteins. However, these bacteria won't be able to add this post translational modifications. So this is definitely also going to be a disadvantage and we're not going to cancel it out and then see they cannot produce active proteins with proper three dimensional confirmation. So this is actually going to be a correct statement as well and we're not going to cancel it out. And since we were not able to cancel out any of the statements in the question, we're going to select answer choice c as the final answer to our question. I really hope this helped you and I hope to see you on the next one.

Why are most recombinant human proteins produced in animal or plant hosts instead of bacterial host cells?

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