A straightforward introduction to Immunology, which helps students focus on the key concepts which explain why the immune system functions as it does - finding a path through the complexity and jargon which can often be daunting for students. This new edition has been thoroughly updated to underline the changes in this fast-moving field.
Clearly guides students through each chapter, using learning objectives, boxed case studies and end-of-chapetr summaries to structure learning - helping students to study more efficiently.
Covers topical areas such as autoimmunity, allergies and AIDS - exciting student interest, and showing them the relevance of immunology.
Simple, clear illustrations help to explain the subject effectively and capture students' interest.
A 4-colour plate section uses photographs to help students visualise important concepts in greater detail.
New to This Edition
All materal has been updated to include recent developments.
New material added to include the anatomy of the lymphoid system.
Expanded section on tumour immunology.
Includes updated and new diagrams where appropriate.
Table of Contents
1 The threat of the body: the role and requirements of the immune system
1.1 The role and complexity of the immune system
1.2 Types of pathogen and how they differ
1.3 Disease production by pathogens
2 The immediate response to infection: innate immunity and the inflammatory response
2.1 The response to infection
2.2 The immediate response to infection -- the innate immune system
2.4 The inflammatory response and cell migration
2.5 Cell migration
2.6 The inflammatory response
2.7 The acute phase response
2.8 Opsonins and phagocytosis
2.9 Interferons and natural killers
3 Specific immune recognition: the antibody molecule
3.1 Introduction to the specific immune system
3.2 Antibody structure
3.3 Recognition by antibody -- antigens and epitopes
3.4 Antibody classes
3.5 Antibody can be secreted or expressed on the cell surface of B lymphocytes
4 T lymphocytes and MHC-associated recognition of antigen
4.1 Overview of T lymphocyte subsets
4.2 The T cell receptor for antigen
4.3 The major histocompatibility complex
4.4 Recognition of antigen by T cells
4.5 Antigen processing and presentation by MHC molecules
5 Generation of diversity: how do T and B cells generate so many different variants of their antigen receptors?
5.2 The relationship between Ig and TcR genes and the proteins produced
5.3 Rearrangement of receptor genes in B and T cells
6 Anatomy of the immune system
6.1 Requirements of the immune system in vivo
6.2 The types of immune response
6.3 Anatomy of the lymphoid system
6.4 Lymphocyte recirculation
7 Cellular and anatomical aspects of antibody production
7.1 Overview of antibody production
7.2 Activation of CD4 T lymphocytes
7.3 Stimulation of B-cells by antigen and their interaction with helper Th (2-4 days after antigen)
7.4 Formation of germinal centres (4-14 days after antigen)
7.5 MALT and the production of IgA
8 Effector mechanisms: dealing with pathogens in vivo (1) Antibody-mediated responses
8.1 Humoral and cell-mediated immunity
8.2 Antibody-mediated effector responses
8.3 Neutralisation by antibody
8.5 Phagocytosis and killing
8.7 Antibody, complement and the opsonisation of microbes