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Anatomy & Physiology: Bones and Bone Structure

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  • Primary functions of the skeletal system

    Support, storage of minerals and lipids, blood cell production, protection, and leverage.

  • Bone classification by shape

    Sutural, irregular, short, flat, long, and sesamoid bones.

  • Sutural bones

    Small, flat, irregularly shaped bones between flat bones of the skull; number varies among individuals.

  • Irregular bones

    Bones with complex shapes, such as spinal vertebrae and pelvic bones.

  • Short bones

    Boxy bones like carpals and tarsals.

  • Flat bones

    Thin bones with parallel surfaces, e.g., skull roof bones, sternum, ribs, and scapulae.

  • Long bones

    Long and slender bones found in arms, legs, palms, soles, fingers, and toes.

  • Sesamoid bones

    Small, round, flat bones developing within tendons near joints, e.g., patellae.

  • Bone markings: projections and openings

    Projections are attachment sites for muscles, tendons, and ligaments; openings and depressions allow passage of blood vessels and nerves.

  • Structure of a long bone

    Diaphysis (compact bone shaft with medullary cavity), epiphysis (mostly spongy bone ends), and metaphysis (junction between diaphysis and epiphysis).

  • Structure of flat bones

    Spongy bone (diploë) sandwiched between two layers of compact bone.

  • Bone matrix composition

    About two-thirds calcium phosphate forming hydroxyapatite crystals and one-third collagen fibers.

  • Osteogenic cells

    Mesenchymal stem cells in periosteum and endosteum that divide to produce osteoblasts and assist in fracture repair.

  • Osteoblasts

    Immature bone cells that produce new bone matrix (osteoid) during ossification; become osteocytes when surrounded by matrix.

  • Osteocytes

    Mature bone cells in lacunae that maintain matrix and help repair damaged bone; connected by canaliculi.

  • Osteoclasts

    Large multinucleate cells that absorb and remove bone matrix by secreting acids and enzymes; important for bone homeostasis.

  • Osteon structure in compact bone

    Functional unit with central canal containing blood vessels, surrounded by concentric lamellae of bone matrix.

  • Spongy bone characteristics

    Lacks osteons; consists of trabeculae with red bone marrow in spaces; nutrients reach osteocytes by diffusion.

  • Periosteum functions

    Covers bone surface except joints; isolates bone, provides blood vessels and nerves, and participates in growth and repair.

  • Endosteum characteristics

    Incomplete cellular layer lining medullary cavity and central canals; active in bone growth, repair, and remodeling.

  • Endochondral ossification

    Bone formation replacing hyaline cartilage; primary ossification center forms inside cartilage; most bones develop this way.

  • Intramembranous ossification

    Bone formation within dermis producing dermal bones like mandible and clavicles; involves direct ossification of mesenchymal tissue.

  • Bone remodeling

    Continuous process involving osteocytes, osteoblasts, and osteoclasts to recycle and renew bone matrix, maintaining bone strength and calcium balance.

  • Effects of exercise on bone

    Weight-bearing exercise stimulates osteoblasts, increasing bone thickness and strength; inactivity leads to rapid bone mass loss.

  • Role of calcium in the skeletal system

    Bones store 99% of body calcium; calcium ions are vital for physiological processes and must be tightly regulated.

  • Parathyroid hormone (PTH) effects

    Increases blood calcium by stimulating osteoclasts, enhancing intestinal absorption via calcitriol, and reducing kidney excretion.

  • Calcitonin effects

    Decreases blood calcium by inhibiting osteoclasts, increasing calcium excretion, reducing calcitriol secretion, and lowering intestinal absorption.

  • Steps in fracture repair

    Fracture hematoma formation, callus formation, spongy bone formation, and compact bone formation.

  • Effects of aging on bones

    Bones become thinner and weaker due to osteopenia; osteoporosis is severe bone loss, especially in women after menopause.