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Anatomy & Physiology: Chemistry for Human Physiology

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  • Definition of matter

    Matter is anything that has mass and occupies volume.

  • Properties of matter

    Mass, volume, density, physical properties, and chemical properties.

  • States of matter found in the human body

    Solid, liquid, and gas.

  • Definition of an element

    An element is a substance composed of atoms with the same number of protons.

  • Common elements important in human physiology

    Carbon (C), Hydrogen (H), Oxygen (O), Nitrogen (N), Calcium (Ca), Phosphorus (P), Sodium (Na), Potassium (K), Chloride (Cl).

  • Basic structure of an atom

    Protons (positive, nucleus), Neutrons (neutral, nucleus), Electrons (negative, orbitals around nucleus).

  • Atomic number (Z)

    The number of protons in an atom; unique to each element and determines its identity.

  • Atomic mass (A)

    The sum of protons and neutrons in the nucleus of an atom.

  • Isotopes

    Atoms of the same element with the same number of protons but different numbers of neutrons; can be stable or radioactive.

  • Octet rule

    Atoms tend to gain, lose, or share electrons to achieve a stable valence shell with eight electrons.

  • Ionic bonds

    Formed by the transfer of electrons, creating cations and anions that attract each other.

  • Covalent bonds

    Formed by sharing electrons between atoms; can be nonpolar or polar.

  • Hydrogen bonds

    Weak bonds between partially charged regions of molecules; important in water, DNA base pairing, and protein structure.

  • Hydrophobic interactions

    Nonpolar substances aggregate in water, important for protein folding and membrane formation.

  • Water's high specific heat

    Water absorbs large amounts of heat with little temperature change, helping stabilize body temperature.

  • Water autoionization

    Water dissociates into H⁺ and OH⁻ ions: H₂O ⇌ H⁺ + OH⁻; at neutral pH, [H⁺] = 10⁻⁷ M.

  • Definition of pH

    pH is the negative logarithm of hydrogen ion concentration, indicating acidity or alkalinity.

  • Role of buffers in physiology

    Buffers resist changes in pH, maintaining homeostasis; examples include bicarbonate, phosphate, and protein buffers.

  • Four major classes of biological macromolecules

    Carbohydrates, lipids, proteins, and nucleic acids.

  • Basic structure of amino acids

    Central carbon, amino group, carboxyl group, hydrogen, and variable R group.

  • Levels of protein structure

    Primary (sequence), secondary (α-helix, β-sheet), tertiary (3D folding), quaternary (multiple subunits).

  • Nucleotides contain

    Nitrogenous base, pentose sugar, and phosphate group(s).

  • Difference between DNA and RNA

    DNA has deoxyribose sugar and thymine; RNA has ribose sugar and uracil instead of thymine.

  • Phospholipid bilayer structure

    Hydrophilic heads face aqueous environments; hydrophobic tails face inward, forming the plasma membrane.

  • Physiological importance of cholesterol

    Maintains plasma membrane structure and fluidity; precursor for steroid hormones, bile acids, and vitamin D.

  • Difference between saturated and unsaturated fatty acids

    Saturated have no double bonds and are linear; unsaturated have one or more double bonds causing kinks.

  • Role of redox reactions in physiology

    Involve electron transfer; essential for cellular respiration, electron transport, ATP production, and metabolism.

  • Examples of physiological ions

    Na⁺, K⁺, Ca²⁺, Mg²⁺, Cl⁻, PO₄³⁻, Fe²⁺/Fe³⁺; involved in membrane potential, muscle contraction, bone formation, oxygen transport, ATP production, acid-base balance.