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Anatomy & Physiology: Nervous System and Membrane Potentials

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  • Central nervous system (CNS)

    The CNS consists of the brain and spinal cord, responsible for processing and integrating information.

  • Peripheral nervous system (PNS)

    The PNS includes all nerves outside the CNS, connecting it to limbs and organs.

  • Cell body (soma)

    The cell body contains the nucleus and organelles; it integrates incoming signals.

  • Dendrite

    Dendrites are branched projections that receive electrical signals from other neurons.

  • Axon

    The axon transmits electrical impulses away from the cell body to other neurons or effectors.

  • Anterograde transport

    Anterograde transport moves materials from the cell body down the axon toward the synapse.

  • Retrograde transport

    Retrograde transport moves materials from the axon terminal back to the cell body.

  • Motor (efferent) neuron

    Motor neurons carry signals from the CNS to muscles or glands to produce a response.

  • Sensory (afferent) neuron

    Sensory neurons transmit information from sensory receptors to the CNS.

  • Association neuron (interneuron)

    Interneurons connect sensory and motor neurons within the CNS for processing.

  • Multipolar neuron

    A multipolar neuron has one axon and multiple dendrites; most common neuron type.

  • Bipolar neuron

    A bipolar neuron has one axon and one dendrite; found in sensory organs like the retina.

  • Unipolar (pseudounipolar) neuron

    A unipolar neuron has a single process that splits into two branches; common in sensory neurons.

  • Anaxonic neuron

    Anaxonic neurons have no distinct axon and are involved in local signal processing.

  • Schwann cell

    Schwann cells myelinate axons in the PNS, aiding faster signal conduction.

  • Satellite cell

    Satellite cells surround neuron cell bodies in ganglia, providing support and nutrients.

  • Myelination and Nodes of Ranvier

    Myelination insulates axons; Nodes of Ranvier are gaps that enable saltatory conduction.

  • Oligodendrocytes

    Oligodendrocytes myelinate axons in the CNS, increasing conduction speed.

  • Microglia

    Microglia act as immune cells in the CNS, removing debris and pathogens.

  • Astrocytes

    Astrocytes support neurons, maintain the blood-brain barrier, and regulate extracellular ions.

  • Ependymal cell

    Ependymal cells line brain ventricles and spinal canal, producing and circulating cerebrospinal fluid.

  • Resting membrane potential

    The resting membrane potential is the voltage across the membrane at rest, typically around -70 mV, due to ion distribution.

  • Graded potentials

    Graded potentials are small, variable changes in membrane potential that can summate to trigger action potentials.

  • Action potentials

    Action potentials are rapid, all-or-none electrical impulses that propagate along axons.

  • Leak channels

    Leak channels allow passive ion flow, contributing to the resting membrane potential.

  • Depolarization

    Depolarization is a decrease in membrane potential making the inside less negative, often due to Na+ influx.

  • Repolarization

    Repolarization restores the membrane potential to resting state, usually by K+ efflux.

  • Hyperpolarization

    Hyperpolarization makes the membrane potential more negative than resting, inhibiting action potential generation.

  • Voltage-gated ion channel

    Voltage-gated channels open or close in response to changes in membrane potential, crucial for action potentials.

  • Absolute vs. relative refractory period

    The absolute refractory period prevents new action potentials; the relative refractory period allows them with stronger stimuli.

  • Saltatory conduction

    Saltatory conduction is the rapid jumping of action potentials between Nodes of Ranvier on myelinated axons.

  • Electrical synapse

    Electrical synapses allow direct ion flow between cells via gap junctions for fast communication.

  • Chemical synapse

    Chemical synapses use neurotransmitters to transmit signals across a synaptic cleft.

  • Excitatory post-synaptic potential (EPSP)

    EPSPs depolarize the postsynaptic membrane, increasing the chance of an action potential.

  • Inhibitory post-synaptic potential (IPSP)

    IPSPs hyperpolarize the postsynaptic membrane, decreasing the chance of an action potential.

  • Divergence

    Divergence is when one neuron sends signals to multiple neurons.

  • Convergence

    Convergence is when multiple neurons send signals to one neuron.

  • Ionotropic receptors

    Ionotropic receptors are ligand-gated ion channels that open quickly to change membrane potential.

  • Metabotropic receptors

    Metabotropic receptors activate second messenger systems, causing slower but longer-lasting effects.

  • Temporal vs. spatial summation

    Temporal summation is rapid repeated stimuli; spatial summation is simultaneous stimuli from multiple synapses.

  • Long-term potentiation (LTP)

    LTP is a long-lasting increase in synaptic strength, important for learning and memory.

  • Long-term depression (LTD)

    LTD is a long-lasting decrease in synaptic strength, involved in synaptic plasticity.

  • Presynaptic inhibition

    Presynaptic inhibition reduces neurotransmitter release from the presynaptic neuron, decreasing signal transmission.