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Anatomy & Physiology: Skeletal System and Bone Biology

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  • Two divisions of the skeleton

    Axial skeleton and appendicular skeleton.

  • Number of bones in the adult skeleton

    Approximately 206 bones.

  • Bones in the axial skeleton

    80 bones including the skull, thorax, and vertebral column.

  • Bones in the appendicular skeleton

    126 bones including limbs and girdles attaching them to the axial skeleton.

  • Five functions of bones

    Support the body, anchor muscles, store minerals and fats, produce blood cells in red marrow, protect organs, and act as levers for movement.

  • Six bone categories based on shape

    Flat, sutural, long, irregular, sesamoid, and short bones.

  • Definition of flat bones

    Thin bones with parallel surfaces that protect tissues and provide muscle attachment areas.

  • Examples of flat bones

    Cranial bones, sternum, ribs, and scapulae.

  • What are sutural bones?

    Irregular bones forming between cranial bones; their number, size, and shape vary.

  • Definition of long bones

    Relatively long and slender bones, such as many limb bones.

  • Definition of irregular bones

    Bones with complex shapes, e.g., vertebrae, pelvic bones, and facial bones.

  • What are sesamoid bones?

    Small, flat bones developing within tendons, such as the patella.

  • Definition of short bones

    Small, box-shaped bones like carpals and tarsals.

  • What is the epiphysis?

    The expanded area at each end of a long bone, mostly spongy bone covered by compact bone.

  • What is articular cartilage?

    Cartilage covering parts of the epiphysis that form joints.

  • What is the metaphysis?

    Region connecting epiphysis to diaphysis; contains the growth plate.

  • What is the diaphysis?

    The shaft of a long bone.

  • What is the medullary cavity?

    The marrow cavity inside the diaphysis of a long bone.

  • Function of red bone marrow

    Produces red blood cells, white blood cells, and platelets.

  • What is yellow bone marrow?

    Marrow containing adipose tissue serving as an energy reserve.

  • What is the periosteum?

    A covering around the outer surface of compact bone.

  • Two layers of the periosteum

    Fibrous outer layer and cellular inner layer.

  • Three functions of the periosteum

    Separates bone from tissues, provides routes for blood vessels and nerves, and aids bone growth and repair.

  • What is the endosteum?

    Cellular layer lining the medullary cavity, covering spongy bone and central canals.

  • When is the endosteum active?

    During bone growth, repair, and remodeling.

  • What is a nutrient foramen?

    An opening allowing blood vessels access to the marrow cavity.

  • What are osteogenic cells?

    Stem cells producing cells that differentiate into osteoblasts; important in fracture repair.

  • Where are osteogenic cells found?

    In the inner periosteum and endosteum lining the medullary cavity.

  • What are osteoblasts?

    Cells that produce new bone matrix and help deposit calcium salts.

  • What is osteoid?

    The unmineralized bone matrix produced by osteoblasts.

  • What is ossification or osteogenesis?

    The process of forming bone.

  • What do osteoblasts become when surrounded by bone matrix?

    Osteocytes.

  • What are osteocytes?

    Mature bone cells maintaining the matrix; they cannot divide.

  • What are lacunae?

    Small pockets in bone matrix containing osteocytes.

  • What are lamellae?

    Layers of bone matrix.

  • What are canaliculi?

    Small channels connecting lacunae and the central canal.

  • What are osteoclasts?

    Cells that remove and remodel bone matrix by releasing acids and enzymes.

  • What is osteolysis?

    The breakdown of bone matrix releasing stored minerals.

  • What gives bone flexibility?

    Collagen fibers, about one-third of bone weight.

  • What gives bone strength?

    Calcium phosphate, about two-thirds of bone weight.

  • Three main layers in bone organization

    Periosteum, compact bone, and spongy bone.

  • Functional unit of compact bone

    The osteon.

  • What is an osteon?

    Structural unit of compact bone with concentric lamellae around a central canal.

  • What are central canals?

    Channels in osteons containing blood vessels and nerves.

  • What are circumferential lamellae?

    Bone matrix layers at outer and inner surfaces of compact bone.

  • What are interstitial lamellae?

    Bone matrix layers filling spaces between osteons.

  • What are perforating canals?

    Canals connecting blood vessels within compact bone.

  • What is spongy bone?

    Bone with lamellae forming trabeculae, creating an open network.

  • Where is red bone marrow found in spongy bone?

    Between the trabeculae.

  • What is appositional growth?

    Increase in diameter of an existing bone.

  • Layers involved in appositional growth

    Periosteum and endosteum.

  • How does appositional growth increase bone diameter?

    Osteoblasts add matrix beneath periosteum; osteoclasts remove matrix from inner surface enlarging medullary cavity.

  • What happens to osteoblasts trapped in new matrix?

    They mature into osteocytes.

  • What is endochondral ossification?

    Replacing a cartilage model with bone.

  • Type of cartilage in initial embryonic skeleton for endochondral ossification

    Hyaline cartilage.

  • How does bone grow in length during endochondral ossification?

    Chondrocytes produce cartilage on epiphyseal side; osteoblasts replace cartilage with bone on diaphyseal side.

  • What is the primary ossification center?

    Central region of cartilage model where bone formation begins in the shaft.

  • What are secondary ossification centers?

    Regions in epiphyses where bone formation begins as capillaries and osteoblasts migrate in.

  • What is the epiphyseal plate?

    Cartilage plate separating epiphysis from diaphysis during bone length growth.

  • What happens to the epiphyseal plate at skeletal maturity?

    Cartilage is replaced by bone, leaving an epiphyseal line.

  • What is intramembranous ossification?

    Bone formation without a prior cartilage model.

  • Examples of bones formed by intramembranous ossification

    Skull roofing bones, lower jaw, collarbone, and sesamoid bones like the patella.

  • What is an ossification center?

    Location where bone formation begins in tissue.

  • First step in intramembranous ossification

    Stem cells cluster, differentiate into osteoblasts, and secrete osteoid that mineralizes.

  • What happens as bone spicules develop in intramembranous ossification?

    Osteoblasts become trapped and mature into osteocytes; stem cells produce more osteoblasts.

  • How does compact bone form during intramembranous ossification?

    Remodeling around blood vessels produces osteons of compact bone.

  • What are minerals in the body?

    Inorganic ions vital for osmotic balance and physiological processes.

  • Most abundant mineral in the body

    Calcium.

  • Percentage of body calcium in the skeleton

    About 99%.

  • Three functions of calcium

    Muscle contraction, blood clotting, and nerve impulse generation.

  • How do intestines maintain calcium levels?

    Absorb calcium and phosphate under hormonal control.

  • How do bones maintain calcium levels?

    Osteoclasts release calcium by eroding matrix; osteoblasts deposit calcium in new matrix.

  • How do kidneys maintain calcium levels?

    Regulate calcium and phosphate loss in urine under hormonal control.

  • Hormones that increase blood calcium levels

    Parathyroid hormone (PTH) and calcitriol.

  • How does PTH increase blood calcium?

    Promotes bone matrix breakdown by osteoclasts and increases calcium absorption and reabsorption.

  • Hormone that decreases blood calcium levels

    Calcitonin.

  • How does calcitonin affect bone?

    Inhibits osteoclast activity and promotes calcium deposition in bone matrix.

  • What is a bone fracture?

    A crack or break caused by extreme mechanical load.

  • What is a closed (simple) fracture?

    A fracture that remains internal with no break in the skin.

  • What is an open (compound) fracture?

    A fracture projecting through the skin, increasing infection and bleeding risks.

  • Four main steps of fracture healing

    Fracture hematoma formation, callus formation, spongy bone formation, and compact bone formation.

  • What is a fracture hematoma?

    A large blood clot closing injured vessels, developing within hours after fracture.

  • What is an internal callus?

    Network of spongy bone uniting inner fracture edges.

  • What is an external callus?

    Cartilage and bone structure stabilizing outer fracture edges.

  • What happens during spongy bone formation in fracture healing?

    Cartilage of external callus is replaced by spongy bone; dead bone and fragments are removed.

  • What happens during compact bone formation in fracture healing?

    Spongy bone is replaced by compact bone; remodeling reduces fracture evidence.