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Anatomy & Physiology: Skin Structure and Layers

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  • Epidermis

    The outermost layer of skin composed mainly of keratinocytes. It provides a protective barrier.

  • Stratum basale

    The deepest layer of the epidermis where new keratinocytes are generated by cell division.

  • Stratum corneum

    The outermost layer of the epidermis made of dead, flattened keratinized cells that provide a tough protective layer.

  • Stratum spinosum

    A layer of the epidermis above the stratum basale where keratinocytes begin producing keratin and develop spiny connections.

  • Stratum lucidum

    A thin, clear layer of dead skin cells found only in thick skin areas like palms and soles.

  • Stratum granulosum

    A layer of the epidermis where keratinocytes accumulate granules of keratohyalin, beginning the process of keratinization.

  • Keratinocytes

    The primary cell type in the epidermis responsible for producing keratin, a protective protein.

  • Keratin

    A fibrous protein produced by keratinocytes that strengthens skin, hair, and nails.

  • Melanocytes

    Cells in the epidermis that produce melanin, the pigment responsible for skin color and UV protection.

  • Dermis

    The thick layer of skin beneath the epidermis containing blood vessels, nerves, and connective tissue.

  • Reticular layer

    The deeper, thicker layer of the dermis composed of dense irregular connective tissue providing strength and elasticity.

  • Papillary layer

    The upper layer of the dermis made of loose connective tissue that forms dermal papillae to support the epidermis.