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bone part 1

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  • number of bones in adults


    206

  • what is in each bone


    bone tissue, dense regular collagenous tissue, dense irregular connective tissue, bone marrow

  • functions of skeletal system


    protection, mineral storage and acid-base homeostasis, blood cell formation, fat storage, movement, support

  • minerals that bone stores


    calcium, phosphorus and magnesium salts

  • what are the minerals used for


    the minerals are electrolytes, acids, and bases in the blood that are crtitical for electrolyte and acid-base maintenance

  • site of hematopoiesis


    red bone marrow

  • where is fat stored


    yellow bone marrow

  • yellow bone marrow contents


    adipocytes and store triglycerides

  • how is movement done


    when muscles contract they pull the bones which generates movement around a joint

  • long bones


    longer than wide, bones of the limbs

  • short bones


    as long as wide, wrist and ankle bones

  • flat bones


    thin and broad, skull and pelvis bones

  • irregular bones


    irregular shape, vertebrae

  • sesamoid bones


    small, flat, oval shaped bones located within tendons, the kneecap

  • periosteum


    outer dense irregular connective tissue membrane with blood vessels and nerves

  • perforating fibers


    collagen anchors that penetrate into bone matrix to attach the periosteum

  • diaphysis


    shaft of the bone with a medullary cavity

  • medullary cavity


    lined by endosteum and filled with marrow

  • epiphysis


    ends of long bone, filled with red marrow, covered with articular cartilage (made of hyaline cartilage)

  • compact bone


    hard dense outer bone that resists linear compression and twisting forces

  • spongy bone


    inner framework that resists forces in many directions, place for bone marrow to reside

  • epiphyseal lines


    whats left of an epiphyseal plate, a line of hyaline cartilage actively growing in children

  • structure of short, flat, irregular and sesamoid bones


    share similarities with long bones but have fewer structures

  • spongy bone in flat bones


    diploe

  • air filled spaces called sinuses


    in some flat and irregular bones of the skull to make the bones lighter

  • blood supply to short, flat, irregular, and sesamoid bones


    provided by vessels in periosteum that penetrate bone

  • blood supply to long bones


    from periosteum and 1 or 2 nutrient arteries

  • nutrient arteries


    enter through a small hole in the diaphysis called the nutrient foramen to supply the internal structures of the long bone

  • red bone marrow


    network of reticular fibers supporting islands of hematopoietic cells, infants have mostly red bone marrow becuase of rapid growth rate

  • inorganic matrix of bone


    65% of bones total weight, calcium salts and phosphorus as part of hydroxyapatite crystals

  • hydroxyapatite crystals function


    give bone its strength and ability to resist compression

  • other components of inorganic matrix


    bicarbonate potassium, magnesium, sodium salts

  • organic matrix of bone


    35% of bones total weight, protein fibers (collagen), bone specific proteins (osteocalcin)

  • collagen function in bones


    helps bone resist torsion and tensile forces, aligns with hydroxyapatite crystals to enhance bone hardness

  • torsion


    twisting

  • tensile


    pulling or stretching

  • osteocalcin function


    binds to calcium ions and hydroxyapatite crystals to organize bones inorganic matrix

  • glycosaminoglycans and proteoglycans function


    draw water out of the blood vessels and cells to help the ECM resist compression

  • glycoproteins function


    bind to both hydroxyapatite crystals and bone cells to bind them together

  • dynamic tissue


    new bone is continually being formed as older bone is broken down

  • osteoblasts


    build bone and matures into osteocytes

  • osteocytes


    maintain bone

  • osteoclasts


    break down bone

  • where are osteoblasts derived from


    osteogenic cells

  • osteoblasts composition


    cubodial to columnar cells in the inner periosteum and endosteum

  • osteoblasts function


    perform the process of bone deposition by secreting organic matrix and assiting in formation of inorganic matrix

  • osteocytes composition


    osteoblasts surround themselves with matrix and become trapped in a cavity called a lacuna

  • osteocytes function


    secrete chemicals to maintain the ECM, recruit osteoblasts to build areas of bone under tension

  • osteoclasts compostion


    large, multinucleate cells with ruffled border, derived from fusion of cells formed in the bone marrow

  • location of osteoclasts


    internal or external surfaces of bone

  • osteoclasts function


    bone resorption ( breaking down bone ECM)

  • Bone resorption


    osteoclasts secrete hydrogen ions that dissolve inorganic matrix , secrete enzymes that break down organic matrix

  • what do osteoclasts deliver to the blood


    minerals, amino acids, sugars

  • units of compact bone


    osteons or haversion systems

  • unit of spongy bone


    organized into branching "ribs" of bone called trabeculae

  • concentric lamellae


    rings of very thin layers of bone, 4 to 20 in osteons, collagen fibers of adjacent lamellae run in opposite directions

  • lamellae function


    resist twisting and bending forces

  • central canal


    contains blood vessels and nerves, lined by endosteum

  • lacunae


    small cavities between lamellae filled with ECF, 20,000-30,000 found in each cubic millimeter of bone

  • canaliculi


    tiny canals that connect lacunae, filled with think cytoplasmic extensions of osteocytes that contact each other through gap junctions

  • how are osteons connected


    interstitial lamellae internally and circumferential lamellae in the inner and outer rings that strengthen bone

  • perforating canals


    connect central canals of neighboring osteons and carry blood vessels from the periosteum to the central canals

  • trabeculae


    covered with endosteum, contain concentric lamellae with lacunae and canaliculi housing osetocytes

  • trabeculae blood supply


    from blood vessels in bone marrow