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Ch. 3 Review

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  • Cells are...


    the smallest living unit that carry out physiological functions in order to maintain homeostasis.

  • Plasma Membrane is ...


    outer boundary of a cell.

  • Functions of a Plasma Membrane...


    regulates: passage of substances

    separates: fluid on the inside/outside

    physical separation:

    sensitivity: receptors allow communication

    support: anchors cells together.

  • Cells have a Phospholipid bilayer that contains ...


    • hydrophilic heads

    • hydrophobic tails

  • Hydrophilic Heads in a phospholipid bilayer...


    heads with POLAR covalent bonds that ATRACT water. (in contact with ECF, ICF)

  • Hydrophobic Tails in a phospholipid bilayer...


    have NONPOLAR covalent bonds which repel ions/water.

  • cholesterol in the plasma membrane...


    a type of lipid that stiffens the plasma membrane making it less of a "fluid" and less permeable.

  • Proteins associated with the plasma membrane...


    integral proteins -> embedded within cell membrane

    transmembrane -> integral proteins that span entire width of membrane

    peripheral proteins -> bound to inner or outer surface of membrane

  • Cytoplasm...


    all material between plasma membrane and membrane of the nucleus.

  • Three major parts of the cytoplasm are...


    • Cytosol (ICF)

    • organelles

    • Inclusions

  • Cytosol (major part of the cytoplasm) is...


    mixture of water + dissolved nutrients, ions, proteins, waste (JELLY-LIKE SUBSTANCE)

  • Organelles of the Cytoplasm are ...


    internal structures with a specific function. ("LITTLE ORGANS")

  • Inclusions in the Cytoplasm are...


    insoluble materials within cells (glycogen granules, skeletal cells)

  • non membranous organelles in the cytoplasm...


    not completely enclosed by membranes -> in direct contact with cytosol.

  • membranous organelles in the cytoplasm...


    are completely enclosed by membrane -> isolated from cytosol.

  • Cytoskeleton of a cell...


    internal framework of proteins in cytoplasm.

  • The three types of cytoskeletal fibers are...


    • microfilaments

    • intermediate filaments

    • microtubules

  • Functions of Microfilaments (smallest) in the cytoskeleton...


    • mechanical strength

    • attaching plasma membrane -> cytoplasm

    • protein interactions that determine -> consistency of cytosol (jelly->)

  • Functions of Intermediate Filaments (medium) in the cytoskeleton...


    • strengthening cell + maintain shape

    • stabilizing organelles

  • Functions of Microtubules (Largest) in the cytoskeleton...


    radiate outward from centrosome

    • cell movement

    • forming spindle apparatus during cell division

  • Centrosome...


    A region of the cytoplasm that organizes microtubules.

  • Centrioles located in the centrosome ...


    a PAIR of cylindrical structures that form spindle apparatus during cell division.

  • Ribosomes...


    organelles that make proteins and are made of two subunits of differing size + rRNA

  • Free Ribosomes...


    scattered throughout cytoplasm that makes protein that goes straight into the fluid.

  • Fixed Ribosomes...


    are attached to the rough endoplasmic reticulum.

  • Endoplasmic Reticulum...


    network of intracellular membranes that are continuous with nuclear envelope.

  • Functions of Endoplasmic Reticulum (ER) are ...


    • makes proteins, carbohydrates, lipids

    • storage

    • transport

    • detoxification

  • Functions of the Smooth endoplasmic Reticulum (SER)...


    lacks fixed ribosomes

    • makes phospholipids/cholesterol

    • makes steroid hormones in reproductive organs

    • making + storage of triglycerides in liver and fat

    • making + storage of glycogen -> skeletal muscle and liver cels

  • Functions of the rough endoplasmic Reticulum (RER)...


    • synthesis of proteins by fixed ribosomes

    • chemical modification of newly made proteins in the RER

    • packages modified proteins -> into transport vesicles

    • the place where proteins fold

  • Golgi Apparatus...


    organelle composed of flattened membranous discs (cisternae) that modifies and packages secretions. Proteins arrive here from the RER

  • Functions of the Golgi Apparatus include...


    Modify and package secretions.

  • Lysosomes are ...


    vesicles produced by Golgi apparatus that contain digestive enzymes.

    • membrane eclosed isolated environment (compartmentalization)

      • enzymatic reaction occurring within lysosomes -> toxic chemicals

  • Functions of Lysosomes...


    • use hydrolysis reaction to break polymers -> monomers -> new organelles

    • recycling damaged organelles

    • killing bacteria

    • autolysis: self-destruction of damaged cells.

  • enzymatic reactions...


    generates toxic chemicals that can end the cell.

  • compartmentalization of lysosomes...


    isolated environed (membrane enclosed) in order to allow enzymatic reactions and autolysis to occur.

  • Mitochondria in a cell tells you...


    the energy demands of a cell, as well as what the cell is doing. (where ATP is made)

  • Nucleus Functions...


    • stores DNA

    • controls which, when, and how many PROTEINS are made.

    • determines cell structure and function.

      Has two bilayers

  • Nuclear envelope...


    double membrane surrounding the nucleus -> connected to the RER

  • nuclear pore...


    openings in the nuclear envelope that allow communication between the nucleus and cytoplasm.

  • Nuclear Pore Complex (NPC)...


    proteins in the nuclear pore that control what goes in and out of the nucleus.

  • Nucleolus...


    organelles INSIDE nucleus that makes ribosomes.

  • nucleosomes...


    DNA coiled around histones (circular proteins)

  • Cells that ARE NOT going to divide...


    have LOOSLEY coiled DNA around histone -> CHROMATIN

  • Cells that WILL divide...


    have TIGHTLY coiled DNA around histone -> CHROMOSOMES

  • Gene...


    DNA nucleotide sequence that codes for amino acid sequence of one protein.

  • central dogma of molecular biology says that...


    DNA sequence is TRANSCRIBED into mRNA, THEN mRNA sequence is TRANSLATED into protein amino acid sequence.

  • Transcription of DNA...


    MAKES RNA from DNA template. DNA is copied to mRNA since mRNA can leaved nucleus using uracil (U).

    • DNA: A -> RNA: U

    • DNA: T-> RNA: A

    • DNA: G-> RNA: C

    • DNA: C-> RNA: G

  • Translation...


    making of a polypeptide by translating info from mRNA -> amino acid of a polypeptide. (tRNA anticodons complementary to mRNA codons)

  • Codons...


    3 bases of sequence that translates into amino acid.

    • DNA: A T A T G G C T A T G C

      Transcribed->

    • mRNA: U A U A C C G A U A C G

  • RNA processing...


    turns immature RNA into a protein by removing introns -> Mature RNA leaves nucleus -> TRANSLATION outside of the nucleus.

  • Diffusion...


    movement of substance from a higher concentration area -> lower concentration. (eliminates gradient)

  • Concentration gradient...


    difference between high/low concentration of substances.

  • Diffusion throughout the plasma membrane uses...


    • simple diffusion

    • channel-mediated diffusion.

  • Simple Diffusion...


    no channel needed, lipid soluble compounds pass through membrane.

  • channel-mediated diffusion...


    water-soluble compounds pass through

  • Osmosis...


    diffusion of water in response to different solute (the thing GETTING dissolved) concentration.

  • Equilibrium...


    concentration is equal on both sides of the membrane.

  • Tonicity...


    describes the shape of cell as a result of concentration of solutes.

  • Isotonic fluid...


    means the solute concentration of ICF/ECF is equal -> no Osmosis

  • hypotonic amount of fluid...


    solute concentration of ICF is higher than ECF -> causing water to enter membrane -> hemolysis (cell burst)

  • hypertonic...


    solute concentration of ICF is lower than ECF water exits

  • carrier-mediated transport...


    movement of a substance across cell membrane using carrier protein (specific to ONE substance).

  • carrier proteins...


    connects ions and carry's them across membrane (specific to ONE substance)

  • symporters...


    carrier proteins that carry two substances in the same direction at the same time.

  • antiporters...


    carries substances in the opposite direction at the same time. (exchange pump)

  • Sodium-Potassium exchange pump...


    exchanges sodium inside cell for potassium outside of the cell.

  • Cell Division divides a cell into 2 daughter cels through...


    mitosis and cytokinesis

  • Mitosis is the division of...


    Body cells.

  • Meiosis is the division of...


    sex cells

  • Interphase is the ___ phase of the CELL LIFE CYCLE...


    FIRST

  • True or False: Interphase is where body cells spend MOST of their life.


    TRUE

  • The 3 MAIN phases where the cell PREPARES TO DIVIDE of Interphase are...


    • G1

    • S

    • G2

  • G0...


    when the cell leaves the life cycle and is NOT ACTIVLEY PREPARING FOR DIVISION!

  • phase G1 of Interphase...


    is the time where CELLS GROW

    • organelles duplicate (enough for TWO cells)

  • phase S of Interphase...


    is when DNA REPLICATION occurs. (one chromosome -> 2 identical daughter cells)

  • Centromere...


    where the two identical daughter cells connect AFTER DNA replication.

    • FORMED BY KINTOCHORE

  • phase G2 of the Interphase...


    is the making of (microtubular) proteins

    • preparing for M phase

  • M PHASE (2nd stage of life cycle) includes...


    Mitosis and cytokinesis

  • Mitosis is the process of division of...


    the nucleus.

  • Cytokinesis is the process of division of...


    cytoplasm. (outside of the nucleus)

  • The Phases of Mitosis (division of the nucleus) are...


    • Prophase \

    • Metaphase PMAT

    • Anaphase /

    • Telophase

  • PROPHASE (1st phase of M phase) ...


    • chromatin condenses -> chromosomes (become visible)

    • nuclear envelope disintegrates

    • microtubules form Mitotic Spindle

  • Kinetochore...


    protein structure that FORMS centromere.

    • give place for spindle to attach too

  • METAPHASE (2nd phase of M phase) ...


    chromatids line up at metaphase plate (the middle)

  • ANAPHASE (3rd phase of M phase) ...


    Chromatid pairs -> SEPERATE

  • TELOPHASE (final phase of M phase) ...


    • nucleus ENLARGES

    • chromosomes GO BACK to chromatin

    • mitotic spindle breaks down (gets recycled)

  • Cytokinesis occurs...


    at the END of anaphase -> Telophase.

  • During Cytokinesis what forms?


    cleavage furrow.

  • The Contractile Band squeezes cells into separation during...


    Cytokinesis.