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Development and Inheritance - Anatomy & Physiology

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  • Development

    Continuous process from fertilization to maturity involving gradual modification of anatomical structures and physiological characteristics.

  • Differentiation

    Creation of different cell types during development through selective changes in genetic activity; some genes turn off, others turn on.

  • Fertilization

    Fusion of a secondary oocyte and spermatozoon forming a zygote with 46 chromosomes (23 pairs).

  • Capacitation

    Process spermatozoa must undergo in female reproductive tract to fertilize the oocyte, involving contact with seminal gland secretions and female tract conditions.

  • Acrosomal Caps

    Release enzymes hyaluronidase and acrosin to penetrate corona radiata and zona pellucida toward oocyte surface during fertilization.

  • Oocyte Activation

    Contact and fusion of sperm and oocyte membranes; oocyte completes meiosis II and becomes mature ovum.

  • Amphimixis

    Fusion of female and male pronuclei; moment of conception when zygote with 46 chromosomes is formed.

  • Gestation

    Period of prenatal development divided into three trimesters: first (embryological and early fetal), second (organ development), and third (rapid growth and organ function).

  • Cleavage

    Sequence of rapid cell divisions after fertilization transforming zygote into multicellular blastocyst.

  • Implantation

    Attachment of blastocyst to uterine endometrium about 7 days after fertilization, initiating embryonic structure formation.

  • Gastrulation

    Formation of three embryonic germ layers (ectoderm, mesoderm, endoderm) via cell migration through primitive streak.

  • Placenta

    Complex organ allowing exchange between maternal and embryonic blood, supporting fetus during second and third trimesters.

  • Human Chorionic Gonadotropin (hCG)

    Hormone produced by placenta soon after implantation; basis for pregnancy tests and supports mammary gland preparation.

  • Relaxin

    Hormone increasing pubic symphysis flexibility, dilating cervix, and delaying labor contractions by suppressing oxytocin release.

  • Parturition

    Forcible expulsion of fetus involving uterine contractions that begin near the top and move toward the cervix.

  • Labor Stages

    Dilation (cervix dilates), expulsion (fetus delivered), and placental (afterbirth ejection) stages.

  • Dizygotic Twins

    Fraternal twins from two separate fertilized oocytes; genetically different.

  • Monozygotic Twins

    Identical twins from splitting of blastomeres or inner cell mass; genetically identical.

  • Postnatal Life Stages

    Neonatal, infancy, childhood, adolescence, maturity, and senescence stages after birth.

  • Genotype vs Phenotype

    Genotype is the genetic makeup; Phenotype is the observable physical and physiological traits.

  • Homologous Chromosomes

    Pairs of chromosomes (23 pairs) in somatic cells; one from each parent.

  • Autosomal Chromosomes

    22 pairs of non-sex chromosomes affecting somatic traits.

  • Sex Chromosomes

    23rd chromosome pair determining genetic sex: XY male, XX female.

  • Alleles

    Different forms of a gene that determine specific traits.

  • Homozygous

    Both chromosomes carry the same allele for a gene.

  • Heterozygous

    Chromosomes carry different alleles for a gene; phenotype depends on allele interaction.

  • Dominant and Recessive Alleles

    Dominant allele is always expressed; recessive allele expressed only if both alleles are recessive.

  • Codominance

    Both dominant and recessive phenotypes are expressed simultaneously.

  • Polygenic Inheritance

    Traits controlled by multiple genes, producing complex phenotypes like hair color and height.

  • Carriers

    Individuals heterozygous for a recessive mutation who do not show symptoms but can pass it to offspring.

  • X-Linked Inheritance

    Genes on X chromosome affecting somatic traits; males more affected due to single X chromosome.