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Metabolism and Nutrient Processing in Anatomy & Physiology

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  • What is metabolism?

    Metabolism is all the chemical reactions that occur in an organism, including catabolic and anabolic reactions.

  • Difference between anabolism and catabolism

    Anabolism synthesizes organic compounds; catabolism breaks down organic compounds.

  • What is the nutrient pool?

    An accessible reserve of organic compounds used for metabolic turnover or energy production.

  • Primary fuel source for most body cells

    Glucose is the primary fuel source absorbed and catabolized by most tissues.

  • Role of NAD and FAD in metabolism

    NAD and FAD are coenzymes that accept hydrogen ions during oxidation, forming NADH and FADH2 for ATP production.

  • Where does carbohydrate digestion begin?

    In the mouth, where salivary amylase breaks down complex carbohydrates into disaccharides and oligosaccharides.

  • What happens to salivary amylase in the stomach?

    It is denatured by the acidic environment (pH below 4.5), stopping carbohydrate digestion.

  • Role of pancreatic amylase

    Breaks down remaining complex carbohydrates into disaccharides and oligosaccharides in the duodenum.

  • Function of brush border enzymes maltase, sucrase, and lactase

    They digest disaccharides into monosaccharides: maltose to glucose, sucrose to glucose and fructose, lactose to glucose and galactose.

  • What is glycogenesis?

    The conversion of excess glucose into glycogen for short-term storage in liver and muscle cells.

  • What is glycogenolysis?

    The breakdown of glycogen to release glucose into the blood when glucose levels are low.

  • What is gluconeogenesis?

    The synthesis of glucose from smaller carbon chains derived from fats or proteins, usually after glycogen depletion.

  • Describe glycolysis

    An anaerobic process in the cytoplasm that oxidizes glucose into two pyruvate molecules, producing a net gain of 2 ATP and 2 NADH.

  • What happens to pyruvate in the presence of oxygen?

    It enters the mitochondria to be converted into acetyl CoA and used in the citric acid cycle.

  • Products of the citric acid cycle per glucose molecule

    8 NADH, 6 CO2, 2 FADH2, and 2 ATP are produced from two acetyl CoA molecules.

  • Role of the electron transport system (ETS)

    Transfers electrons from NADH and FADH2 through cytochromes to oxygen, producing 32 ATP and 6 H2O molecules.

  • Overall equation for glucose catabolism

    C6H12O6 + 6O2 → 6CO2 + 6H2O + 36 ATP + heat

  • Hormones regulating glucose catabolism

    Insulin lowers blood sugar by stimulating glycogenesis and glucose catabolism; glucagon raises blood sugar by stimulating glycogenolysis and gluconeogenesis.

  • How are lipids digested and absorbed?

    Emulsified by bile, broken down by pancreatic lipase into fatty acids and monoglycerides, absorbed by brush border cells, reassembled into chylomicrons, and transported via lymph.

  • What is beta-oxidation?

    An enzymatic process in mitochondria that breaks fatty acids into acetyl CoA units, producing ATP efficiently.

  • Essential fatty acids

    Fatty acids with double bonds before carbon #9 that the body cannot synthesize, e.g., Omega-3 and Omega-6.

  • Protein digestion in the stomach

    Pepsinogen is activated to pepsin by stomach acid, breaking proteins into smaller peptides.

  • Pancreatic proteases in protein digestion

    Trypsin, chymotrypsin, carboxypeptidase, and elastase break peptides into smaller peptides and amino acids in the small intestine.

  • Amino acid catabolism and urea cycle

    Deamination removes amino groups, producing ammonium ions converted to urea in the liver for safe excretion.

  • Basal metabolic rate (BMR)

    The minimum resting energy expenditure of an awake, alert person.

  • Heat-loss mechanisms in thermoregulation

    Include sweating, vasodilation, radiation, conduction, convection, evaporation, and behavioral changes.

  • Heat-promoting mechanisms

    Include vasoconstriction, increased metabolic rate, shivering, behavioral changes, and enhanced thyroxine release.

  • Role of hypothalamus in thermoregulation

    Acts as the body's thermostat, integrating signals from thermoreceptors and initiating heat loss or production responses.

  • Fat-soluble vitamins and their significance

    Vitamins A, D, E, and K are absorbed with lipids and are essential for epithelial maintenance, bone growth, antioxidant functions, and blood clotting.

  • Water-soluble vitamins and their significance

    B vitamins and vitamin C act mainly as coenzymes in metabolism and must be regularly consumed as they are not stored extensively.