What does a rightward shift in the oxygen binding curve indicate about hemoglobin's oxygen affinity in tissues?

If the KD value decreases in the lungs, what happens to hemoglobin's oxygen affinity?

How does a decrease in pH in tissues affect hemoglobin's oxygen affinity according to Le Chatelier's principle?

How does cellular respiration in tissues contribute to hemoglobin's oxygen release?

What role does carbonic anhydrase play in the cycle of hemoglobin from lungs to tissues?

If fractional saturation decreases in tissues, what is the effect on oxygen release?

What role does myoglobin play in the cycle of hemoglobin from lungs to tissues?