Biochemistry
Why is the GDP to GTP exchange in heterotrimeric G proteins crucial for adenylate cyclase activation?
A mutation prevents cAMP from binding to protein kinase A. What is the likely cellular consequence?
How do the stimulatory and inhibitory pathways of adenylate cyclase GPCR signaling differ in their effects on cAMP levels?
What is the role of beta adrenergic receptor kinase and beta arrestin in GPCR desensitization?
A drug inhibits cAMP phosphodiesterase. What is the expected effect on cellular signaling?
A mutation prevents GDP from being released from the alpha subunit. What is the likely effect on adenylate cyclase?
A drug prevents dephosphorylation of proteins by phosphatases. What is the expected effect on cellular signaling?
