What specific point mutation in the beta subunit of hemoglobin leads to sickle cell anemia?

How does the substitution of valine for glutamate in hemoglobin affect protein folding?

How does being heterozygous for the sickle cell trait provide resistance to malaria?

What are the primary health complications associated with sickle cell anemia?

If two heterozygous individuals for the sickle cell trait have a child, what is the probability that the child will have sickle cell anemia?

How does the sickle shape of red blood cells affect their ability to travel through small blood vessels?

In a malaria-endemic region, which genotype provides the best balance between health and malaria resistance?