Which amino acids are phosphorylated by receptor tyrosine kinases?

In a scenario where a receptor tyrosine kinase is mutated and cannot undergo transautophosphorylation, what would be the most likely consequence?

Which method of receptor activation inhibition would be most effective in permanently stopping a receptor from signaling?

How does the PI3K/AKT pathway promote cell survival?

A drug is developed to specifically inhibit receptor serine/threonine kinases. What would be the expected effect on the TGF-beta signaling pathway?

How does Ras function as a signaling hub in receptor tyrosine kinase pathways?

Evaluate the potential impact of a PI3K inhibitor on cancer cells.