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Anatomy & Physiology: Cell Structure and Membrane Transport

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  • Levels of Structural Organization in the Human Body

    From smallest to largest: Atoms → Molecules → Cells → Tissues → Organs → Organ Systems → Organism.

  • Basic Parts of a Human Cell

    Plasma membrane (flexible outer boundary), cytoplasm (intracellular fluid with organelles), and nucleus (control center).

  • Fluid Mosaic Model of Plasma Membrane

    Membrane is a phospholipid bilayer with embedded proteins that move, creating a fluid mosaic structure.

  • Integral vs Peripheral Membrane Proteins

    Integral proteins are embedded in the membrane; peripheral proteins are loosely attached and often enzymes or structural supports.

  • Functions of Membrane Proteins

    Include transport, receptors for signal transduction, attachment to cytoskeleton and ECM, enzymatic activity, intercellular joining, and cell-cell recognition.

  • Tight Junctions

    Membrane junctions that prevent fluids and most molecules from passing between cells, creating an impermeable barrier.

  • Desmosomes

    Anchoring junctions that act like rivets to bind adjacent cells and reduce tension by linking to intermediate filaments.

  • Gap Junctions

    Communicating junctions with pores allowing ions and small molecules to pass directly between cells for intercellular communication.

  • Passive Transport

    Movement of substances across membranes without energy, usually down concentration gradients (high to low).

  • Simple Diffusion

    Passive movement of nonpolar and lipid-soluble substances directly through the lipid bilayer.

  • Facilitated Diffusion

    Passive transport of lipid-insoluble solutes via carrier proteins or channel proteins down their concentration gradient.

  • Osmosis

    Passive movement of water across a selectively permeable membrane toward higher solute concentration.

  • Tonicity Effects on Cells

    Isotonic: no net water movement; Hypertonic: water leaves cell causing shrinkage; Hypotonic: water enters cell causing swelling or lysis.

  • Filtration

    Passive process where water and solutes are forced through membranes by hydrostatic pressure, size-selective, important in kidneys.

  • Active Transport

    Energy-requiring process moving solutes against their concentration gradient using carrier proteins (pumps).

  • Sodium-Potassium Pump

    Active transport pump that moves 3 Na+ out and 2 K+ into the cell using ATP, maintaining electrochemical gradients.

  • Vesicular Transport

    Active transport of large particles or fluids via vesicles, including exocytosis, endocytosis, and transcytosis.

  • Phagocytosis

    Type of endocytosis where cells engulf large particles or microorganisms using pseudopods forming a phagosome.

  • Pinocytosis

    Non-specific endocytosis where cells 'gulp' extracellular fluid and solutes into tiny vesicles.

  • Receptor-Mediated Endocytosis

    Selective endocytosis where ligands bind to specific receptors in coated pits, concentrating substances for internalization.