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Anatomy & Physiology: Eye Structure and Visual Function

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  • Fibrous layer of the eyeball

    The outermost layer composed of dense avascular connective tissue, including the sclera and cornea. It protects and shapes the eyeball and anchors extrinsic eye muscles.

  • Sclera

    Opaque posterior region of the fibrous layer that protects the eyeball and anchors extrinsic eye muscles. Continuous with dura mater where the optic nerve exits.

  • Cornea

    Transparent anterior one-sixth of the fibrous layer that allows light to enter and bends light. Covered by epithelium with pain receptors triggering blinking and tearing reflexes.

  • Vascular layer (uvea) of the eye

    Middle pigmented layer consisting of the choroid, ciliary body, and iris. Supplies blood and absorbs light to prevent scattering.

  • Choroid

    Posterior portion of the uvea that supplies blood to all layers of the eyeball and contains brown pigment to absorb light.

  • Ciliary body

    Thickened ring of tissue surrounding the lens with ciliary muscles that control lens shape and ciliary processes that secrete aqueous humor.

  • Iris and pupil function

    The iris is the colored part of the eye controlling pupil size. The pupil regulates light entry: sphincter pupillae constricts it under parasympathetic control; dilator pupillae dilates it under sympathetic control.

  • Inner layer (retina) structure

    Two-layered membrane with an outer pigmented layer that absorbs light and an inner neural layer containing photoreceptors, bipolar cells, and ganglion cells.

  • Photoreceptors: rods vs cones

    Rods detect dim light and peripheral vision without color; cones detect bright light and color with high resolution.

  • Macula lutea and fovea centralis

    Macula lutea is an area with mostly cones; fovea centralis is a pit in the macula with only cones, providing the sharpest vision.

  • Optic disc (blind spot)

    Site where the optic nerve exits the eye; lacks photoreceptors, creating a blind spot.

  • Internal chambers of the eye

    Divided by the lens into anterior and posterior segments filled with aqueous humor and vitreous humor, respectively.

  • Aqueous humor

    Plasma-like fluid in the anterior segment, produced by ciliary processes, supplying nutrients and draining via the scleral venous sinus.

  • Vitreous humor

    Gel-like fluid in the posterior segment that transmits light, supports the lens, holds the retina in place, and maintains intraocular pressure.

  • Lens structure and function

    Biconvex, transparent, flexible, and avascular; changes shape to focus light on the retina. Lens fibers contain crystallin protein and increase in density with age.

  • Refraction in the eye

    Bending of light rays occurs at the cornea and lens to focus light on the retina. The cornea provides most refractive power but cannot change focus.

  • Accommodation for close vision

    Ciliary muscles contract to loosen the ciliary zonule, allowing the lens to bulge and increase refraction for focusing on close objects.

  • Pupil constriction and dilation

    Sphincter pupillae contracts to constrict the pupil under parasympathetic control; dilator pupillae contracts to dilate the pupil under sympathetic control.

  • Phototransduction process

    Light changes retinal from 11-cis to all-trans form in visual pigments, activating transducin and phosphodiesterase, leading to cGMP breakdown and photoreceptor hyperpolarization.

  • Rod vs cone vision sensitivity

    Rods are highly sensitive to dim light but do not detect color; cones require bright light and provide color vision with high acuity.

  • Visual pigment regeneration

    All-trans retinal is converted back to 11-cis retinal to regenerate rhodopsin, allowing photoreceptors to respond to light again.

  • Light and dark adaptation

    Light adaptation reduces rod sensitivity and constricts pupils; dark adaptation increases rod sensitivity and dilates pupils to improve vision in low light.

  • Visual pathway to the brain

    Retinal ganglion cell axons form the optic nerve; fibers partially cross at the optic chiasma, continuing as optic tracts to the lateral geniculate nucleus and primary visual cortex.

  • Depth perception

    Results from the brain fusing slightly different images from each eye, creating a three-dimensional view requiring input from both eyes.