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Anatomy & Physiology: Integumentary System and Skin Structure

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  • Epidermis

    The superficial layer of skin made of stratified squamous keratinized epithelium. It is avascular and relies on diffusion from the dermis for oxygen and nutrients.

  • Dermis

    The deeper skin layer composed of loose and dense irregular collagenous connective tissue, including the papillary and reticular layers.

  • Hypodermis

    Also called subcutaneous tissue, it is the layer of adipose tissue beneath the skin.

  • Eccrine Sweat Glands

    Glands producing watery sweat for thermoregulation. They are the most numerous and active throughout life.

  • Apocrine Sweat Glands

    Located in axillae, anal area, and areola; secrete thick, protein-rich sweat active after puberty. Bacterial breakdown causes odor.

  • Functions of the Integumentary System

    Protection, sensation, thermoregulation, excretion, and synthesis of vitamin D for calcium absorption.

  • Negative Feedback in Body Temperature Control

    If too hot, thermoreceptors signal hypothalamus to induce sweating and vasodilation; if too cold, vasoconstriction and blood redirection conserve heat.

  • Layers of the Epidermis (top to bottom)

    Stratum corneum, stratum lucidum (only in thick skin), stratum granulosum, stratum spinosum, stratum basale. Mnemonic: Come Let’s Get Sun Burned.

  • Keratinocytes

    Make up 95% of epidermis; produce keratin which protects against mechanical damage and water loss.

  • Stratum Basale

    Lowest epidermal layer where most mitosis occurs.

  • Stratum Spinosum

    The thickest epidermal layer.

  • Stratum Granulosum

    Layer where cells fill with keratin.

  • Stratum Lucidum

    Clear layer found only in thick skin (palms and soles).

  • Stratum Corneum

    Top epidermal layer; cells take 40-50 days to migrate here.

  • Dendritic (Langerhans) Cells

    Immune system phagocytes that protect skin and deeper tissues.

  • Merkel Cells

    Oval cells in stratum basale that detect light touch and texture.

  • Melanocytes

    Cells that produce melanin, the pigment protecting against UV radiation.

  • Callus

    Thickened area of stratum corneum formed by repetitive pressure.

  • Papillary vs Reticular Dermis

    Papillary layer is superficial with loose connective tissue; reticular layer is deeper with dense irregular connective tissue.

  • Lamellated (Pacinian) Corpuscles

    Sensory receptors in reticular dermis detecting pressure and vibration; resemble onion layers.

  • Epidermal Ridges

    Folded epidermal patterns in thick skin that improve grip and form fingerprints.

  • Melanin

    Brown-black to orange-red pigment from melanocytes that protects skin from UV radiation.

  • Carotene

    Orange pigment found in foods like carrots and sweet potatoes.

  • Hemoglobin

    Iron-containing red pigment in red blood cells that binds oxygen.

  • Cyanosis

    Blue skin color due to lack of oxygen.

  • Erythema

    Redness from increased blood flow in the dermis, such as during exercise or fever.

  • Pallor

    Loss of skin color due to decreased blood flow in the dermis.

  • Hair Structure

    Hair shaft projects above skin; root is embedded in follicle within dermis.

  • Arrector Pili

    Smooth muscle that contracts to make hair stand on end (goosebumps).

  • Types of Hair

    Lanugo: fetal, thin, non-pigmented; Vellus: thin, non-pigmented; Terminal: thick, coarse, pigmented hair replacing vellus at puberty.

  • Nail Anatomy

    Nail plate rests on nail bed; nail body is visible part; eponychium is cuticle; hyponychium anchors nail plate distally; lunula is half-moon proximal region.

  • Burn Degrees

    First degree: red, painful, no permanent damage; Second degree: partial thickness, blisters, may scar; Third degree: full thickness, often requires grafts.

  • Rule of Nines

    Body divided into 11 sections of 9% each plus 1% perineum to estimate burn severity and guide treatment.

  • Skin Cancer Types

    Basal cell carcinoma: least metastatic; Squamous cell carcinoma: keratinocyte cancer, more metastatic; Malignant melanoma: melanocyte cancer, most metastatic.

  • ABCDE Rule for Skin Cancer Detection

    A: Asymmetry, B: Border irregularity, C: Color variation, D: Diameter, E: Evolving changes in mole.