Four interconnected, fluid-filled chambers: paired lateral ventricles, third ventricle, fourth ventricle, and the central canal extending into the spinal cord.
Function of cerebrospinal fluid (CSF)
Buoyancy reducing brain weight by 97%, protection cushioning brain from shocks, and chemical stability nourishing tissue and removing waste.
Where is CSF produced?
In the choroid plexus, a cluster of capillaries in each ventricle surrounded by ependymal cells and pia mater.
Pathway of CSF circulation
Produced in choroid plexus → ventricles → subarachnoid space via median and lateral apertures → absorbed into dural venous sinuses through arachnoid granulations.
What is hydrocephalus?
Condition caused by obstruction of CSF flow leading to abnormal accumulation; causes head enlargement in newborns and increased intracranial pressure in adults.
Name the three meninges layers
Dura mater (tough outer layer), arachnoid mater (middle layer with CSF-filled space), and pia mater (delicate inner layer adhering to brain).
Functions of the limbic system
Involved in emotion, memory, and motivation; includes amygdala, hippocampus, cingulate gyrus, and olfactory bulb.
Role of the amygdala in the limbic system
Processes fear and aggression responses.
What is the reticular activating system (RAS)?
A brainstem network that maintains consciousness and alertness by relaying sensory stimuli to the cerebrum.
Broca’s area function
Responsible for speech production in the left hemisphere.
Wernicke’s area function
Responsible for language comprehension in the left hemisphere.
Difference between nonfluent and fluent aphasia
Nonfluent aphasia: lesion in Broca’s area causing slow, labored speech. Fluent aphasia: lesion in Wernicke’s area causing normal but nonsensical speech.
Types of memory
Declarative (facts/events), procedural (skills), motor (motor skills), and emotional (emotional experiences).
Stages of memory storage
Short-term memory (temporary, hippocampus) and long-term memory (permanent, cerebral cortex).
What is amnesia?
Memory loss; retrograde is loss before event, anterograde is inability to form new memories after event.
Brain waves measured by EEG are used to diagnose what?
Epilepsy, sleep disorders, brain lesions, and brain death.
What regulates sleep and sleep-wake cycles?
The reticular activating system and hypothalamic suprachiasmatic nuclei.
Difference between NREM and REM sleep
NREM has four stages from light to deep sleep; REM occurs ~90 minutes in with dreaming and increased vital signs.
Gross structure of the spinal cord
Extends from foramen magnum to L1/L2 vertebra; ends in conus medullaris; cauda equina is nerve bundle below.
Spinal cord meninges and spaces
Dura mater, arachnoid mater, pia mater; epidural space outside dura with fat; subdural and subarachnoid spaces between layers.
What is spina bifida?
Congenital defect where vertebrae fail to form completely, exposing spinal cord; folic acid reduces risk.
Organization of spinal cord gray matter
Dorsal horn: sensory interneurons; ventral horn: motor neurons; lateral horn: autonomic motor neurons (thoracic/lumbar).
Organization of spinal cord white matter
Myelinated axons in dorsal, ventral, and lateral columns called funiculi.