Chapter 5 - The Skeletal System: Osseous Tissue and Skeletal Structure - Exam I
Termini in questo insieme (51)
The skeletal system is made up of what components
skeleton
cartilages
ligaments
other CT that stabilize them
what is the major component of the skeletal system
bone tissue OR osseous tissue
Is the bone highly vascularized and innervated?
yes
List the 5 functions of the skeletal system
Support (body's infrastructure)
Storage of minerals (98% of calcium in bones)
Blood cell production
Protection (surrounds many delicate organs)
Leverage (muscles pull on bone to produce movement)
Structure of BONE (aka ___):
____ connective tissue
outer covering called ____ that's made of _____
inner cellular lining called the ____
osseous tissue
supporting
periosteum; DICT
endosteum
the periosteum is continuous with the ____ fascia, NOT the ____ fascia
deep; superficial
the periosteum holds onto the bone via ____
Sharpey's fibers
The matrix of mature bones is called what?
osteoid
What is the matrix made of in mature bones?
2/3 calcium phosphate (hydroxyapatite)
1/2 collage fibers
what are the cells found in mature bones
osteocytes
osteoblasts
osteoprogenitor cells (won't ask about this)
osteoclasts
which bone cell is a mature cell that maintains bone tissue
osteocyte
which cell is an immature, active cell of the bone that's found in inner and outer surfaces of bone.
What do these cells produce?
osteoblasts
osteoid (matrix)
____ are giant multinucleated cells that break down osteoid and release calcium and phosphate
osteoclasts
Perforating or ____ canals extend ____ to the surface of the bone and connects ____ to one another
Volkman's
perpendicular
osteons
_____ fill in spaces between osteons of compact bones
interstitial lamellae
____ form outer and inner rings on surface of shaft
circumferential lamallae
osteons and central canals are only present in ___ bones
compact
which structures of the bone are present in both spongy and compact bone?
lacunae
lamellae
____ are channels that radiate through the matrix and connect lacuna to one another
canaliculi
____ are the rings found around central canals in osteons
concentric lamellae
a single ___ resides inside a lacunae of bone tissue
osteocyte
spongy bone aka ___ or ____
trabeculae
cancellous
____ spiral around concentric lamellae at opposite angles, creating a very strong structure
collagen
What are the 3 different parts of long compact bones
epiphyses
diaphysis
metaphysis (endochondral or epiphyseal growth plate)
the ____ is the shaft of a long bone
diaphysis
the ___ are the ends of a long bone
epiphyses
the ___ is the layer that connects the epiphyses and diaphysis
metaphysiis
The ____ serves several functions:
____ and ____ the bone from surrounding tissue
provides a ____ and a place of ___ circulatory and nervous supply
actively participates in bone ____ and ____ by having cells that will become osteoblasts
attaches the ____ to the ____
periosteum
isolates and protects
route; attachment
growth and repair
connective tissue; deep fascia
what are the 2 layers of the periosteum
fibrous layer (dense fibrous CT)
cellular layer (contains osteoprogenitor cells)
___ is bone formation
____ is the process of depositing calcium salts into tissues
osteogenesis
calcification
what are the two ways that ossification occurs? Which one makes most of our bones?
Intramembranous ossification
Endochondral ossification (main one)
which bones are made via intramembranous ossification
skull, roofing bones of skull, part of mandible
clavicles
Intramembranous ossification
____ cells aggregate, differentiate into ____, and begin the ossification process. The bone expands as a series of ____ that spread into surrounding tissue
mesenchymal; osteoblasts; spicules
Steps of Intramembranous Ossification
As the spicules ____, they trap ___ within the bone
interconnect; blood vessels
Steps of the Intramembranous ossification
Over time, the bone assumes the structure of ___ bone. Areas of this region may later be removed, creating _____. Through remodeling, spongy bone may be converted into ____ bone.
spongy; medullary cavities; compact
Endochondral Ossification
As the cartilage enlarges, ___ near the center of the shaft increase in size. The ___ is reduced to a series of small ___ that soon begin to ___. The enlarged ____ then die and disintegrate, leaving ____ within the cartilage.
chondrocytes
matrix; struts; calcify
chondrocytes; cavities
Endochondral Ossification
___ grow around the edges of the cartilage, and the cells of the ____ convert into ____. The shaft of the cartilage the becomes ensheathed in a superficial layer of ____
blood vessels
periosteum
osteoblasts
bone
Endochondral ossification
Blood vessels penetrate the ____ and invade the _____. ____ migrating with the blood vessels differentiate into ____ and begin producing ____ bone at its primary center of ossification. Bone formation then spreads along the ____ towards the ____
cartilage; central region
Fibroblasts; osteoblasts; spongy
shaft; ends
Endochondral Ossification
Remodeling occurs as growth continues, creating a _____. The bone of the shaft becomes ___, and the cartilage near each epiphysis is replaced by shafts of ____. Further growth involves increases in ____ and ____
medullary cavity
thicker
bone
length and diameter
Endochondral ossification
___ and ____ migrate into the ____, creating a secondary ossification center
capillaries and osteoblasts
epiphyses
Endochondral ossification
Soon the epiphyses are filled with ____ bone. An ____ cartilage remains exposed to the joint cavity; over time it will be reduced to a thin superficial layer. At each metaphysis, an _____ cartilage separates the epiphysis from the diaphysis
spongy
articular
epiphyseal
____ is a distinct line indicating the former location of epiphyseal cartilage
epiphyseal line
When infants are growing adult bones, what type of growth do they go through? Please describe it
appositional growth (diameter enlarges though growth at the outer surface of bone)
What are the ions and vitamins that typically regulate bone growth
Ions: calcium, phosphate, Mg, citrate, carbonate, sodium
Vitamins: A, C, and D (needed to absorb calcium and phosphate in blood)
____ acts to increase the overall availability of calcium ions in the blood via increased ____ activity
___ is the antagonist of the above and inhibits ____ activity
Parathyroid hormone (PTH); osteoclasts
calcitonin; osteoclasts
Name the epiphyseal plate growth zones
Resting cartilage
Proliferating cartilage
Hypertrophic cartilage
Calcified cartilage
Ossification
Describe zone of resting cartilage
cartilage attaches to the epiphyses
Describe zone of proliferating cartilage
new cartilage is produced on the epiphyseal side of the plate as chondrocytes divide and form stacks of cells
Describe zone of hypertrophy
chondrocytes mature and enlarge
Describe zone of calcification
matrix is calcified and chondrocytes die
Describe ossification of bone after growth
calcified cartilage on the diaphyseal side of the plate is replaced by bone