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Which molecule represents the intermediate step between glycolysis and the citric acid cycle?
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Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism
Pyruvate Oxidation
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In cellular respiration, which process directly connects glycolysis to the citric acid cycle by converting pyruvate into acetyl-CoA?
A
Fermentation of pyruvate to lactate to regenerate
B
Pyruvate oxidation by the pyruvate dehydrogenase complex (oxidative decarboxylation of pyruvate to acetyl-CoA)
C
Oxidation of acetyl-CoA to during the citric acid cycle
D
Conversion of glucose to pyruvate via glycolysis
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Identify the key molecules involved: glycolysis produces pyruvate, and the citric acid cycle uses acetyl-CoA as a substrate.
Understand that the process connecting glycolysis to the citric acid cycle must convert pyruvate into acetyl-CoA.
Recognize that this conversion is catalyzed by the pyruvate dehydrogenase complex through oxidative decarboxylation.
Write the overall reaction for pyruvate oxidation: \(\text{Pyruvate} + \text{CoA} + \text{NAD}^+ \rightarrow \text{Acetyl-CoA} + \text{CO}_2 + \text{NADH}\).
Note that this step links the two pathways by producing acetyl-CoA, which then enters the citric acid cycle for further oxidation.
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