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General Biology: Chemical Basis of Life and Macromolecules

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  • What is matter?

    Matter is anything that occupies space and has mass, existing in solid, liquid, or gas states.

  • Define element and compound.

    Element: a substance that cannot be broken down by normal chemical means.
    Compound: a substance made of two or more elements combined in a fixed ratio with different properties than its elements.

  • What are the Big Six elements in living matter?

    O, C, H, N (96% of living matter) plus P and Ca, which are major components of bones and teeth.

  • What defines an atom's chemical properties?

    Its electrons, especially the valence electrons in the outermost shell.

  • What is an isotope?

    Atoms of the same element with the same number of protons but different numbers of neutrons.

  • Describe an ionic bond.

    Transfer of electrons from one atom to another, creating oppositely charged ions that attract each other.

  • What is a covalent bond?

    Sharing of electrons between atoms to fill their valence shells.

  • Difference between polar and nonpolar covalent bonds?

    Nonpolar: electrons shared equally.
    Polar: electrons pulled closer to the more electronegative atom, creating partial charges.

  • What is a hydrogen bond?

    A weak bond involving hydrogen attracted to oxygen or nitrogen in polar molecules.

  • Why does ice float on liquid water?

    Hydrogen bonds form a 3D crystal that spaces molecules farther apart, making ice less dense than liquid water.

  • What is a buffer?

    A substance that minimizes pH changes by accepting or donating H+ ions.

  • What is an organic compound?

    A carbon-based molecule, usually also containing hydrogen.

  • What is a functional group?

    Specific clusters of atoms attached to carbon skeletons that determine chemical behavior.

  • What reaction links monomers into polymers?

    Dehydration reaction: monomers are linked by removing a water molecule.

  • What reaction breaks polymers into monomers?

    Hydrolysis: polymers are broken down by adding water.

  • Name the monomers of carbohydrates.

    Monosaccharides, such as glucose, fructose, and galactose.

  • What are the main polysaccharides and their functions?

    Starch (plant energy storage), glycogen (animal energy storage), cellulose (plant cell wall structure).

  • Describe saturated vs unsaturated fats.

    Saturated fats have no double bonds and are solid at room temperature; unsaturated fats have double bonds causing kinks and are liquid.

  • What is the structure and role of phospholipids?

    Glycerol + 2 fatty acids + phosphate head; form bilayers with hydrophilic heads facing water and hydrophobic tails inside, making cell membranes.

  • List the four levels of protein structure.

    Primary: amino acid sequence.
    Secondary: alpha helices and beta sheets from backbone hydrogen bonds.
    Tertiary: 3D folding from R group interactions.
    Quaternary: assembly of multiple polypeptide chains.

  • What causes protein denaturation?

    Heat, pH changes, or salt disrupt protein shape and function.

  • What are nucleotides composed of?

    A five-carbon sugar, a phosphate group, and a nitrogenous base.

  • Difference between DNA and RNA bases?

    DNA has thymine (T); RNA has uracil (U) instead of thymine.

  • Write the photosynthesis chemical equation.

    Reactants: 6 CO2 + 6 H2O; Products: C6H12O6 + 6 O2; powered by sunlight.

  • Why is blood pH tightly controlled?

    Because small changes can be fatal; buffers maintain pH near 7.4 by accepting or donating H+.

  • What is electronegativity?

    An atom's attraction for shared electrons in a covalent bond.

  • What is an ion?

    An atom with an electrical charge due to gain or loss of electrons.

  • What is cohesion in water?

    Molecules of the same kind sticking together via hydrogen bonds.

  • Explain evaporative cooling.

    The hottest molecules evaporate first, lowering the average temperature of the remaining liquid.