Biology relies on chemistry and physics to understand life processes, as principles from these fields inform biological functions at molecular and atomic levels.
Major Elements in the Human Body
Key elements include carbon, hydrogen, oxygen, and nitrogen, which make up the majority of living matter and are essential for biological molecules.
Properties of Water Essential for Life
Water exhibits cohesion, adhesion, high surface tension, density variations, and solvent capabilities, all critical for biological processes and ecosystems.
Cohesion vs. Adhesion
Cohesion is attraction between like molecules; adhesion is attraction between unlike molecules, both vital for water transport in plants.
Water Density Anomaly
Ice is less dense than liquid water due to hydrogen bonding forming an open crystal structure, allowing ice to float and insulate aquatic life.
Water as a Solvent
Water's polarity enables it to dissolve ionic and polar substances, making it an excellent solvent for hydrophilic molecules but not hydrophobic ones.
Chemical Reactions and Energy
Reactions transform reactants to products with energy changes; equilibrium occurs when forward and reverse rates are equal, maintaining constant concentrations.
Gibbs Free Energy and Reaction Spontaneity
A reaction is spontaneous if ΔG < 0, non-spontaneous if ΔG > 0, and at equilibrium if ΔG = 0; spontaneity depends on energy and entropy changes.
Carbon's Role in Biology
Carbon's four valence electrons allow diverse covalent bonds, forming complex molecules like hydrocarbons essential for life’s molecular diversity.
Functional Groups in Organic Molecules
Groups like hydroxyl, carboxyl, amino, and phosphate determine chemical properties and reactivity of biological molecules.
Isomers and Their Biological Importance
Isomers have the same formula but different structures, affecting properties; enantiomers are mirror images with distinct biological activities.
Macromolecules and Polymer Formation
Carbohydrates, proteins, and nucleic acids form polymers via condensation reactions; hydrolysis breaks them down, both essential for metabolism.
Carbohydrate Classification
Monosaccharides are simple sugars; disaccharides are two monosaccharides linked; polysaccharides are long chains serving energy storage or structure.
Protein Structure Levels
Proteins have primary (amino acid sequence), secondary (alpha helices, beta sheets), tertiary (3D shape), and quaternary (multi-chain) structures.
Amino Acid Structure
Amino acids have a central carbon, hydrogen, amino group, carboxyl group, and variable R group determining their properties.
Peptide Bonds
Peptide bonds link amino acids via dehydration reactions, forming polypeptide chains with directionality from N-terminus to C-terminus.
DNA vs RNA Structure
DNA contains deoxyribose sugar and thymine; RNA contains ribose sugar and uracil; both are nucleic acids made of nucleotides.
Central Dogma of Molecular Biology
Genetic information flows from DNA to RNA to protein, dictating cellular function and phenotype.
Enzyme Function
Enzymes are proteins that catalyze reactions by lowering activation energy, with specificity determined by their active sites.
Factors Affecting Enzyme Activity
Temperature, pH, and substrate concentration influence enzyme shape and function; extreme conditions can denature enzymes.
Types of Lipids
Lipids include fats (energy storage), steroids (signaling molecules), and phospholipids (membrane structure), all hydrophobic.
Phospholipid Bilayer
Phospholipids have hydrophilic heads and hydrophobic tails, forming bilayers that create selective barriers in cell membranes.
Membrane Proteins
Integral and peripheral proteins facilitate transport, signaling, and structural support within the fluid-mosaic membrane model.
Diffusion and Osmosis
Diffusion is passive movement of molecules down concentration gradients; osmosis is water movement across membranes toward higher solute concentration.
Active Transport and Sodium-Potassium Pump
Active transport uses ATP to move ions against gradients; Na+/K+-ATPase pumps 3 Na+ out and 2 K+ in, maintaining membrane potential.
Cell Cycle Phases
Eukaryotic cell cycle includes G1 (growth), S (DNA synthesis), G2 (preparation), and M phase (mitosis and cytokinesis) for cell division.
Mitosis Stages
Mitosis includes prophase, prometaphase, metaphase, anaphase, and telophase, ensuring equal chromosome segregation to daughter cells.
Cytoskeleton Components
Actin filaments, intermediate filaments, and microtubules provide structural support, enable movement, and organize intracellular transport.
Cell Signaling Steps
Cell signaling involves reception, signal transduction, and response, allowing cells to adapt to environmental changes.