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General Biology: Membrane Transport and Cell Signaling

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  • Membrane Transport

    The movement of substances across a cell membrane, including passive and active mechanisms.

  • Phospholipids

    Amphipathic molecules forming the bilayer of membranes, with hydrophilic heads and hydrophobic tails.

  • Fluid Mosaic

    Model describing the membrane as a fluid combination of lipids, proteins, and carbohydrates.

  • Selective Permeability

    The membrane's ability to allow some substances to pass while blocking others.

  • Homeostasis

    The maintenance of stable internal conditions within a cell or organism.

  • Electro-chemical Gradient

    A gradient of electrical charge and chemical concentration across a membrane that drives ion movement.

  • Amphipathic

    Molecules having both hydrophilic and hydrophobic regions, like phospholipids.

  • Saturated vs Unsaturated Fatty Acids

    Saturated fatty acids have no double bonds; unsaturated have one or more, affecting membrane fluidity.

  • Cholesterol

    A lipid that stabilizes membrane fluidity by preventing tight packing of phospholipids.

  • Membrane Proteins / Integral Proteins

    Proteins embedded in the membrane that assist in transport, signaling, and structural support.

  • Major Functions of Membrane Proteins

    Transport, enzymatic activity, signal transduction, cell recognition, intercellular joining, and attachment.

  • Glycoproteins and Glycolipids

    Membrane carbohydrates covalently bonded to proteins or lipids, important for cell recognition.

  • Gradient

    A difference in concentration or charge that drives diffusion or transport across membranes.

  • Osmosis

    Diffusion of water across a selectively permeable membrane from low to high solute concentration.

  • Osmoregulation

    The control of water balance within a cell or organism to maintain homeostasis.

  • Tonicity: Hypertonic vs Hypotonic

    Hypertonic solutions cause cells to lose water; hypotonic solutions cause cells to gain water.

  • Diffusion

    Passive movement of molecules from high to low concentration without energy input.

  • Passive vs Active Transport

    Passive transport requires no energy; active transport uses energy to move substances against gradients.

  • Channel Proteins, Carrier Proteins, Gated Ion Channels

    Proteins that facilitate selective transport of ions and molecules across membranes.

  • Electrogenic Pumps

    Membrane proteins that generate voltage across membranes by moving ions, e.g., sodium-potassium pump.

  • Sodium-Potassium Pump

    Active transport pump that moves 3 Na+ out and 2 K+ into the cell, maintaining membrane potential.

  • Proton Pump

    Active transporter that moves H+ ions across membranes, creating a proton gradient.

  • Membrane Potential

    The voltage difference across a membrane due to ion distribution.

  • Cotransport: Uniporter, Symporter, Antiporter

    Uniporter moves one substance; symporter moves two in same direction; antiporter moves two in opposite directions.

  • Bulk Transport: Endocytosis and Exocytosis

    Processes that move large molecules or particles into (endocytosis) or out of (exocytosis) the cell.

  • Phagocytosis vs Pinocytosis

    Phagocytosis engulfs large particles; pinocytosis ingests extracellular fluid and solutes.

  • Intercellular vs Intracellular Signaling

    Intercellular signaling occurs between cells; intracellular signaling occurs within a cell.

  • Autocrine Signaling

    Cells respond to signals they themselves release.

  • Paracrine Signaling

    Signals affect nearby target cells.

  • Synaptic Signaling

    Neurons release neurotransmitters to signal adjacent cells across synapses.

  • Endocrine Signaling

    Hormones travel through the bloodstream to distant target cells.

  • Signal Transduction

    The process by which a signal is converted into a cellular response.

  • Ligands and Receptors

    Ligands are signaling molecules that bind to specific receptors to initiate signaling.

  • G Protein-Coupled Receptors (GPCRs)

    Membrane receptors that activate G proteins to relay signals inside the cell.

  • Intracellular Receptors

    Receptors located inside the cell that bind hydrophobic ligands like steroid hormones.

  • Signal Amplification

    Process where a small signal triggers a large cellular response through cascades.

  • Phosphorylation, Kinase, Phosphatase

    Phosphorylation adds phosphate groups via kinases; phosphatases remove them, regulating protein activity.

  • Second Messengers

    Small molecules like cyclic AMP that relay and amplify signals inside the cell.

  • Cyclic AMP (cAMP)

    A common second messenger that activates protein kinase A to regulate cellular processes.