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Modes of Selection and Population Genetics in General Biology

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  • Directional selection

    Directional selection favors one extreme phenotype, shifting the average trait value in a population and reducing genetic variation.

  • Stabilizing selection

    Stabilizing selection favors intermediate phenotypes, reducing variation by selecting against extremes and maintaining the average trait value.

  • Disruptive selection

    Disruptive selection favors extreme phenotypes at both ends, increasing variation and often creating a bimodal distribution.

  • Balancing selection

    Balancing selection maintains multiple phenotypes in a population by mechanisms like heterozygote advantage or frequency-dependent selection, preserving genetic variation.

  • Effect of directional selection on genetic variation

    Directional selection reduces genetic variation as alleles for the favored phenotype increase in frequency and others decline.

  • Effect of stabilizing selection on genetic variation

    Stabilizing selection reduces genetic variation by decreasing the frequency of alleles producing extreme phenotypes.

  • Effect of disruptive selection on genetic variation

    Disruptive selection maintains or increases genetic variation by favoring alleles for both extremes.

  • Effect of balancing selection on genetic variation

    Balancing selection maintains genetic variation by preserving multiple alleles or phenotypes in the population.

  • Darwin's four postulates for natural selection

    1. Variation exists in a trait.
    2. Trait variation is heritable.
    3. More offspring are produced than survive.
    4. Survival and reproduction are non-random with respect to the trait.

  • Gene pool

    The gene pool is the total collection of alleles for all genes in a population.

  • Hardy-Weinberg equilibrium assumptions

    Random mating, no natural selection, no genetic drift, no gene flow, and no mutation.

  • Hardy-Weinberg genotype frequency formulas

    Genotype frequencies predicted by allele frequencies: \(p^2\) for homozygous dominant, \(2pq\) for heterozygous, and \(q^2\) for homozygous recessive.

  • Definition of evolution

    Evolution is a change in allele frequencies in a population over time.

  • Mechanisms that break Hardy-Weinberg equilibrium

    Nonrandom mating, natural selection, genetic drift, gene flow, and mutation cause populations to evolve by changing allele frequencies.

  • Genetic drift

    Genetic drift is random changes in allele frequencies, especially important in small populations, often reducing genetic variation.

  • Gene flow

    Gene flow is the movement of alleles between populations, which can increase or decrease genetic variation.

  • Mutation

    Mutation is the random production of new alleles, increasing genetic variation but often with fitness costs.

  • Heterozygote advantage example

    In sickle cell disease, heterozygotes (carrying one normal and one sickle allele) have higher fitness in malaria regions due to resistance, illustrating balancing selection.

  • Quantitative traits

    Quantitative traits are influenced by many genes and environmental factors, showing continuous variation often with a bell-shaped distribution.

  • How stabilizing selection maintains variation

    Stabilizing selection reduces extremes but random mating, Mendelian segregation, and new mutations rebuild and maintain some genetic variation.

  • Example of directional selection in nature

    Soapberry bugs evolved shorter beaks to feed on introduced plants with smaller fruits, showing directional selection shifting trait averages.

  • Example of disruptive selection in nature

    Bluegill males show disruptive selection: large males guard nests, small males sneak fertilizations, and intermediate males have lower fitness.

  • Frequency-dependent selection

    A form of balancing selection where the fitness of a phenotype depends on its frequency; rare forms have higher fitness.

  • Effect of natural selection on fitness

    Natural selection increases average fitness by favoring alleles that improve survival and reproduction.