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Primary Lymphoid Organs definitions

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Termini in questo insieme (15)

  • Hematopoiesis
    The process of blood cell formation, including the production of T and B lymphocytes in the red bone marrow.
  • Lymphocytopoiesis
    The formation of lymphocytes, specifically T and B cells, originating in the red bone marrow.
  • Immunocompetent
    The state of being capable of carrying out an effective immune response against specific pathogens.
  • Thymus
    A bilobed organ in the mediastinum essential for T cell maturation and selection, part of the lymphatic, immune, and endocrine systems.
  • Mediastinum
    The region in the upper chest behind the sternum, between the lungs, and above the heart, where the thymus is located.
  • Blood-thymus barrier
    A barrier formed by thymic epithelial cells preventing antigens in the blood from disrupting T cell maturation in the thymus.
  • Trabeculae
    Inward capsular extensions of dense irregular connective tissue dividing the thymus lobes into smaller lobules.
  • Lobules
    Smaller compartments within each lobe of the thymus, containing an outer cortex and an inner medulla.
  • Outer cortex
    The region in thymic lobules where premature T cells begin their maturation process.
  • Inner medulla
    The region in thymic lobules containing mature T cells, marked by lighter staining in micrographs.
  • Thymic corpuscles
    Concentric whorls of thymic epithelial cells in the inner medulla, involved in regulatory T cell development.
  • Regulatory T cells
    A special type of T cell developed in the thymus, important for preventing autoimmune diseases.
  • Adipose tissue
    Fatty tissue that accumulates in the thymus as it atrophies with age, replacing thymic tissue.
  • Thymic epithelial cells
    Specialized cells in the thymus forming the blood-thymus barrier and thymic corpuscles, secreting signaling molecules.
  • Thymic atrophy
    The process of the thymus decreasing in size and activity over time, with tissue replaced by fibrous and fatty tissue.