Rochelle developed multiple sclerosis when she was 27. After eight years she had lost a good portion of her ability to control her skeletal muscles. How did this happen?

Local anesthetics block voltage-gated Na⁺ channels. General anesthetics are thought to activate chemically gated Cl⁻ channels, thereby rendering the nervous system quiescent while surgery is performed. What specific process do anesthetics impair, and how does this interfere with nerve impulse transmission?

When admitted to the emergency room, Sean was holding his right hand, which had a deep puncture hole in its palm. He explained that he had fallen on a nail while exploring a barn. Sean was given an antitetanus shot to prevent neural complications. Tetanus bacteria fester in deep, dark wounds, but how do their toxins travel in neural tissue?

The effects of neurotransmitter binding are very brief. Explain.

In the Netherlands a young man named Jan was admitted to the emergency room. He and his friends had been to a rave. His friends say he started twitching and having muscle spasms which progressed until he was 'stiff as a board.' On examination, staff found a marked increase in muscle tone and hyperreflexia involving facial and limb muscles. In his pocket, he had unmarked dark yellow tablets with dark flecks. Analysis of the tablets showed them to contain a mixture of ecstasy and strychnine. Ecstasy would not cause this clinical picture, but strychnine, which blocks glycine receptors, could. Explain how.