Perforins are proteins associated with the activity of
(a) T cells
(b) B cells
(c) NK cells
(d) Plasma cells

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Understand the role of perforins: Perforins are proteins that create pores in the membranes of target cells, leading to cell lysis and death.

Identify which immune cells use perforins: Perforins are primarily used by cytotoxic cells to destroy infected or abnormal cells.

Recall that T cells, specifically cytotoxic T lymphocytes (CTLs), use perforins to kill virus-infected cells.

Recognize that Natural Killer (NK) cells also use perforins to destroy target cells without prior sensitization.

Conclude that both T cells (cytotoxic) and NK cells are associated with perforin activity, but since the question asks for the best match, NK cells (option c) are the classic cells known for perforin-mediated cytotoxicity.

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Perforins

Perforins are proteins that create pores in the membranes of target cells, leading to cell lysis. They are crucial in the immune response for destroying infected or abnormal cells by allowing entry of cytotoxic molecules.

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6:21

Functions of Cytotoxic T Cells

Natural Killer (NK) Cells

NK cells are a type of lymphocyte involved in the innate immune system. They use perforins and granzymes to kill virus-infected cells and tumor cells without prior sensitization.

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6:53

Natural Killer Cells

Cytotoxic T Cells

Cytotoxic T cells (a subset of T cells) recognize and kill infected or cancerous cells by releasing perforins and granzymes. They are part of the adaptive immune response and require antigen presentation for activation.

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