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Ch. 27 Fluids & Electrolytes
Martini - Fundamentals of Anatomy & Physiology 12th Edition
Martini, Nath, Bartholomew12th EditionFundamentals of Anatomy & PhysiologyISBN: 9780137854011Non è quello che usi tu?Cambia libro di testo
Capitolo 26, Problema 6

The most important factor affecting the pH of body tissues is the concentration of:
(a) Lactic acid
(b) Ketone bodies, 
(c) Metabolic acids
(d) Carbon dioxide
(e) Hydrochloric acid

Guida verificata passo dopo passo
1
Step 1: Understand that pH is a measure of hydrogen ion concentration in a solution, and in body tissues, pH is tightly regulated to maintain homeostasis.
Step 2: Recognize that various acids can influence tissue pH, but the most significant factor is related to the respiratory and metabolic processes that produce acids or acid equivalents.
Step 3: Recall that carbon dioxide (CO\_2) dissolves in body fluids to form carbonic acid (H\_2CO\_3), which dissociates into hydrogen ions (H\^+) and bicarbonate (HCO\_3\^-), directly affecting pH.
Step 4: Compare the options: lactic acid and ketone bodies are metabolic acids but usually have a lesser immediate effect on tissue pH compared to CO\_2, which is continuously produced and regulated via respiration.
Step 5: Conclude that the concentration of carbon dioxide is the most important factor affecting the pH of body tissues because it directly influences the acid-base balance through the carbonic acid-bicarbonate buffering system.

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pH and Acid-Base Balance in Body Tissues

pH measures the acidity or alkalinity of body fluids, crucial for cellular function. Body tissues maintain a narrow pH range, and deviations can disrupt enzyme activity and metabolism. Understanding factors that influence pH helps explain how the body regulates acid-base balance.
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01:29
Acids and Bases

Role of Carbon Dioxide in pH Regulation

Carbon dioxide (CO2) dissolves in body fluids forming carbonic acid, which dissociates into hydrogen ions and bicarbonate, directly affecting pH. CO2 levels are tightly regulated by respiration, making it the primary factor influencing tissue pH through the respiratory component of acid-base balance.
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Metabolic Acids and Their Impact on pH

Metabolic acids, such as lactic acid and ketone bodies, are produced during metabolism and can lower pH if accumulated. While they contribute to acid-base disturbances, their effect is generally less immediate and less significant than CO2 in normal tissue pH regulation.
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Pratica correlata
Domanda del libro di testo

Osmoreceptors in the hypothalamus monitor the osmotic concentration of the ECF and secrete _______ in response to higher osmotic concentrations. 

(a) BNP

(b) ANP

(c) aldosterone

(d) ADH

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Domanda del libro di testo

Metabolic alkalosis occurs when:

(a) Bicarbonate ion concentrations become elevated

(b) A severe bicarbonate loss occurs

(c) The kidneys fail to excrete hydrogen ions

(d) Ketone bodies are generated in abnormally large quantities

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Domanda del libro di testo

Write the missing names and molecular formulas for the following reactions between the carbonic acid–bicarbonate buffer system and the bicarbonate reserve.

a. ___

b. ___

c. ___

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Domanda del libro di testo

Changes in the pH of body fluids are compensated for by all of the following except:

(a) An increase in urine output

(b) The carbonic acid–bicarbonate buffer system

(c) The phosphate buffer system

(d) Changes in the rate and depth of breathing

(e) Protein buffers

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Domanda del libro di testo

Respiratory acidosis develops when the blood pH is:

(a) Increased due to a decreased blood P𝒸ₒ₂ level

(b) Decreased due to an increased blood P𝒸ₒ₂ level

(c) Increased due to an increased blood P𝒸ₒ₂ level

(d) Decreased due to a decreased blood P𝒸ₒ₂ level

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Domanda del libro di testo

Calcium homeostasis primarily reflects:

(a) A balance between absorption in the gut and excretion by the kidneys

(b) Careful regulation of the blood calcium level by the kidneys

(c) An interplay between parathyroid hormone and aldosterone, 

(d) An interplay among reserves in the bones, the rate of absorption, and the rate of excretion

(e) Hormonal control of calcium reserves in the bones

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