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Which enzyme primarily initiates the hydrolysis of dietary starch in humans?
A
Trypsin
B
Lipase
C
Pepsin
D
Amylase (e.g., salivary α-amylase)
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1
Identify the substrate involved in the problem: dietary starch, which is a polysaccharide composed of glucose units.
Recall that hydrolysis of starch involves breaking down the glycosidic bonds between glucose units to produce smaller sugars like maltose and glucose.
Consider the location where starch digestion begins in humans, which is the mouth, and the enzyme responsible for initiating this process.
Recognize that amylase, specifically salivary \(\alpha\)-amylase, is the enzyme that catalyzes the hydrolysis of starch into smaller oligosaccharides during chewing.
Understand that other enzymes listed (trypsin, lipase, pepsin) target proteins or lipids, not carbohydrates, so they do not initiate starch hydrolysis.