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In oxidative phosphorylation, what is the primary role of NADH in cellular respiration?
A
It serves as the final electron acceptor, combining with electrons and protons to form water.
B
It transports oxygen from the lungs to tissues to support aerobic metabolism.
C
It directly catalyzes the phosphorylation of ADP to ATP at ATP synthase.
D
It donates high-energy electrons to Complex I of the electron transport chain, helping drive proton pumping across the inner mitochondrial membrane.
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Understand the role of NADH in cellular respiration, specifically in the context of oxidative phosphorylation.
Recall that NADH is a reduced coenzyme that carries high-energy electrons derived from metabolic pathways like glycolysis and the citric acid cycle.
Recognize that NADH donates these high-energy electrons to Complex I (NADH dehydrogenase) of the electron transport chain located in the inner mitochondrial membrane.
Know that the transfer of electrons from NADH through Complex I initiates a series of redox reactions that pump protons (H\+ ions) from the mitochondrial matrix to the intermembrane space, creating a proton gradient.
This proton gradient then drives ATP synthesis by ATP synthase, but NADH itself does not directly catalyze ATP formation or act as the final electron acceptor.