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Which of the following molecules is a net product of glycolysis (per glucose molecule) under aerobic conditions?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
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During glycolysis (per molecule of glucose), how many ATP molecules are produced on a net basis?
A
0 ATP
B
36 ATP
C
4 ATP
D
2 ATP
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Understand that glycolysis is the metabolic pathway that breaks down one molecule of glucose into two molecules of pyruvate, producing energy in the form of ATP and NADH.
Identify the ATP-consuming steps: In the energy investment phase of glycolysis, 2 ATP molecules are used to phosphorylate glucose and its intermediates.
Identify the ATP-producing steps: In the energy payoff phase, 4 ATP molecules are generated through substrate-level phosphorylation when 1,3-bisphosphoglycerate and phosphoenolpyruvate are converted to their respective products.
Calculate the net ATP production by subtracting the ATP consumed from the ATP produced: Net ATP = ATP produced - ATP consumed = 4 - 2.
Conclude that the net ATP yield per glucose molecule during glycolysis is 2 ATP molecules.
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