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During glycolysis (from one molecule of glucose to two molecules of pyruvate), what is the net gain of ATP per glucose molecule?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
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In glycolysis (from one molecule of glucose to two molecules of pyruvate), what is the net production of ATP?
A
0 ATP (net)
B
36 ATP (net)
C
2 ATP (net)
D
4 ATP (net)
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Understand the overall process of glycolysis: one molecule of glucose (6 carbons) is converted into two molecules of pyruvate (3 carbons each).
Identify the ATP investment phase: during the early steps of glycolysis, 2 ATP molecules are consumed to phosphorylate glucose and its intermediates.
Identify the ATP payoff phase: later steps generate ATP by substrate-level phosphorylation, producing 4 ATP molecules in total (2 ATP per pyruvate).
Calculate the net ATP production by subtracting the ATP invested from the ATP produced: Net ATP = ATP produced - ATP consumed.
Conclude that the net ATP yield from glycolysis per glucose molecule is 2 ATP.
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