Domanda aperta
Indicate with an 'x' which of the kinetic parameters would be altered in the presence of the given inhibitor.
170
views
2
rank
7. Enzyme Inhibition and Regulation
Noncompetitive Inhibition
Scelta multipla
Which of the following equilibrium expressions best represents noncompetitive inhibition of an enzyme?
A
E + S + I \(\rightleftharpoons\) ESI
B
E + S \(\rightleftharpoons\) ES;\(\quad\) E + I \(\rightleftharpoons\) EI;\(\quad\) ES + I \(\rightleftharpoons\) ESI
C
E + S \(\rightleftharpoons\) ES;\(\quad\) E + I \(\rightleftharpoons\) EI
D
E + S \(\rightleftharpoons\) ES;\(\quad\) ES + I \(\rightleftharpoons\) ESI
Guida verificata passo dopo passo1
Step 1: Begin by understanding the concept of noncompetitive inhibition. Noncompetitive inhibition occurs when an inhibitor binds to an enzyme at a site other than the active site, affecting the enzyme's activity regardless of whether the substrate is bound or not.
Step 2: Analyze the equilibrium expressions provided in the problem. Each expression represents interactions between the enzyme (E), substrate (S), and inhibitor (I). The goal is to identify which expression accurately represents noncompetitive inhibition.
Step 3: Recall that in noncompetitive inhibition, the inhibitor can bind to both the free enzyme (E) and the enzyme-substrate complex (ES). This means that equilibrium expressions should include both E + I forming EI and ES + I forming ESI.
Step 4: Compare the given options. The correct equilibrium expression for noncompetitive inhibition should include: E + S ⇌ ES; E + I ⇌ EI; ES + I ⇌ ESI. This reflects the inhibitor binding to both the free enzyme and the enzyme-substrate complex.
Step 5: Eliminate incorrect options. For example, expressions that do not include ES + I ⇌ ESI or fail to show the inhibitor binding to both E and ES are not representative of noncompetitive inhibition.
Video correlati
Pratica correlata
