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In glycolysis (from one molecule of glucose), how many ATP molecules are produced as the net yield (ATP produced minus ATP consumed) under typical cellular conditions?
A
8 ATP (net)
B
2 ATP (net)
C
0 ATP (net)
D
4 ATP (net)
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1
Understand the glycolysis pathway: Glycolysis converts one molecule of glucose into two molecules of pyruvate, producing energy in the form of ATP and NADH.
Identify ATP consumption steps: In the energy investment phase, 2 ATP molecules are consumed to phosphorylate glucose and its intermediates.
Identify ATP production steps: In the energy payoff phase, 4 ATP molecules are produced by substrate-level phosphorylation (2 ATP per each of the two 3-carbon molecules formed).
Calculate net ATP yield: Subtract the ATP consumed from the ATP produced using the formula: \(\text{Net ATP} = \text{ATP produced} - \text{ATP consumed}\).
Apply the numbers: \(\text{Net ATP} = 4 - 2\), which gives the net yield of ATP molecules produced from one glucose molecule during glycolysis.