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Most enzymes are classified as which type of biological macromolecule?
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6. Enzymes and Enzyme Kinetics
Enzymes
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In cholinergic synapses, the enzyme responsible for rapidly hydrolyzing acetylcholine to terminate neurotransmission is called which of the following?
A
Choline acetyltransferase
B
Butyrylcholinesterase (pseudocholinesterase)
C
Acetylcholinesterase
D
Monoamine oxidase
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Understand the role of acetylcholine in cholinergic synapses: it is a neurotransmitter that transmits signals between neurons or from neurons to muscles.
Recognize that to terminate the signal, acetylcholine must be rapidly broken down after it has transmitted the signal.
Identify the enzyme responsible for this rapid hydrolysis of acetylcholine in the synaptic cleft, which ensures the signal is stopped promptly.
Differentiate between the enzymes listed: Choline acetyltransferase synthesizes acetylcholine, but does not break it down; Butyrylcholinesterase hydrolyzes other choline esters but is not the primary enzyme in synapses; Monoamine oxidase breaks down monoamine neurotransmitters, not acetylcholine.
Conclude that the enzyme acetylcholinesterase is the one that rapidly hydrolyzes acetylcholine in cholinergic synapses to terminate neurotransmission.
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