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Which of the following statements about integral proteins is NOT correct?
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10. Lipids
Integral Membrane Proteins
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Integral membrane proteins are proteins that:
A
Loosely associate with the membrane.
B
Can be released from the membrane by slightly changing the pH.
C
Can be released from the membrane by slightly changing the ionic strength of the solution.
D
Penetrate or span the membrane.
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Understand the definition of integral membrane proteins: Integral membrane proteins are embedded within the lipid bilayer of cell membranes and often span the entire membrane.
Differentiate between integral and peripheral membrane proteins: Integral membrane proteins are permanently attached and require more drastic measures to be removed, whereas peripheral proteins are loosely attached and can be removed by changes in pH or ionic strength.
Consider the structural characteristics: Integral membrane proteins have hydrophobic regions that interact with the lipid bilayer, allowing them to penetrate or span the membrane.
Evaluate the options given: Options a, b, and c describe characteristics of peripheral membrane proteins, which are not embedded within the membrane.
Conclude with the correct characteristic: Integral membrane proteins penetrate or span the membrane, making option d the correct choice.
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