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During which phase of mitosis do sister chromatids separate?
A
Prophase
B
Telophase
C
Metaphase
D
Anaphase
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1
Understand the process of mitosis: Mitosis is the division of a cell's nucleus into two identical nuclei, and it consists of several phases: prophase, metaphase, anaphase, and telophase.
Review the role of sister chromatids: Sister chromatids are identical copies of a chromosome that are connected by a centromere. They are formed during DNA replication in the S phase of the cell cycle.
Examine the events of anaphase: During anaphase, the sister chromatids are pulled apart by the spindle fibers attached to the centromeres. This separation ensures that each new daughter cell receives an identical set of chromosomes.
Compare anaphase to other phases: In prophase, chromosomes condense and spindle fibers begin to form. In metaphase, chromosomes align at the cell's equatorial plane. In telophase, the separated chromatids are enclosed in new nuclear envelopes, completing the division.
Conclude that the separation of sister chromatids is a defining feature of anaphase, distinguishing it from the other phases of mitosis.