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During which phase of mitosis are chromatids held together by centromeres?
A
Telophase
B
Prophase
C
Anaphase
D
Metaphase
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1
Understand the structure of a chromosome: Each chromosome consists of two sister chromatids held together by a centromere.
Review the phases of mitosis: Mitosis is divided into several phases: prophase, metaphase, anaphase, and telophase.
Focus on metaphase: During metaphase, chromosomes align at the metaphase plate, and the sister chromatids are held together by centromeres.
Compare with other phases: In prophase, chromosomes condense but are not yet aligned. In anaphase, sister chromatids are separated and pulled to opposite poles. In telophase, the chromatids have already separated.
Conclude that during metaphase, chromatids are held together by centromeres, which is crucial for proper alignment and separation during mitosis.