Scelta multipla
Why are lethal dominant alleles generally rarer in populations compared to lethal recessive alleles?
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12. Meiosis
Genes & Alleles
Scelta multipla
Why are individuals who are heterozygous for the cystic fibrosis allele unaffected by the disease?
A
Heterozygous individuals have a mutation that prevents the disease.
B
They have one normal allele that produces enough functional protein.
C
The cystic fibrosis allele is only expressed in homozygous individuals.
D
The cystic fibrosis allele is dominant, so it does not express the disease.
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Understand the concept of alleles: Alleles are different forms of a gene. In the case of cystic fibrosis, there are two alleles - one normal and one mutated.
Learn about heterozygosity: A heterozygous individual has two different alleles for a particular gene, one from each parent. For cystic fibrosis, this means having one normal allele and one mutated allele.
Explore protein production: The normal allele produces a functional protein that is necessary for normal cellular function. This protein is called CFTR (Cystic Fibrosis Transmembrane Conductance Regulator).
Consider the effect of the normal allele: In heterozygous individuals, the presence of one normal allele is sufficient to produce enough functional CFTR protein to prevent the symptoms of cystic fibrosis.
Understand expression in homozygous individuals: Cystic fibrosis manifests in individuals who are homozygous for the mutated allele, meaning they have two copies of the mutated allele and no normal allele to produce functional CFTR protein.
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