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The oxygen saturation of hemoglobin ______ as the partial pressure of oxygen (\(pO_2\)) increases.
A
remains constant
B
fluctuates randomly
C
decreases
D
increases
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1
Understand the relationship between oxygen saturation of hemoglobin and partial pressure of oxygen (
). Hemoglobin binds oxygen in a reversible manner, and its saturation depends on the availability of oxygen.
Recall the oxygen-hemoglobin dissociation curve, which is a sigmoidal (S-shaped) curve. This curve shows that as the partial pressure of oxygen (
) increases, hemoglobin's affinity for oxygen also increases, leading to higher oxygen saturation.
Analyze the options provided: 'remains constant,' 'fluctuates randomly,' 'decreases,' and 'increases.' Based on the dissociation curve, oxygen saturation does not remain constant, fluctuate randomly, or decrease as
increases.
Conclude that the correct answer is 'increases,' as higher
levels result in more oxygen binding to hemoglobin, increasing its saturation.
To further understand, consider physiological examples: in the lungs, where
is high, hemoglobin becomes highly saturated with oxygen, while in tissues, where
is lower, hemoglobin releases oxygen to meet cellular needs.