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Threshold is of great significance in the physiology of neurons. What happens if threshold is not reached?
A
The neuron cannot regain its resting potential
B
The action potential will be "inversed," with a flux of sodium out of the cell rather than into it
C
An action potential will be reached
D
None of the listed responses is correct.
E
Positive-feedback depolarization will not occur
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1
Understand the concept of 'threshold' in the context of neuron physiology. The threshold is the critical level to which a membrane potential must be depolarized to initiate an action potential.
Recognize that an action potential is an all-or-nothing event. If the threshold is not reached, the neuron will not fire an action potential.
Consider the role of sodium (Na+) channels in action potential generation. When the threshold is reached, voltage-gated Na+ channels open, leading to a rapid influx of Na+ ions and further depolarization.
If the threshold is not reached, these voltage-gated Na+ channels remain closed, preventing the positive-feedback loop of depolarization necessary for an action potential.
Conclude that without reaching the threshold, positive-feedback depolarization will not occur, and thus, no action potential will be generated.