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Ch. 45 - Animal Movement
Freeman - Biological Science 8th Edition
Freeman8th EditionBiological ScienceISBN: 9780138276263Non è quello che usi tu?Cambia libro di testo
Capitolo 45, Problema 2

In muscle cells, myosin molecules continue moving along actin molecules as long as:
a. ATP is present and troponin is not bound to Ca²⁺.
b. ADP is present and tropomyosin is released from intracellular stores.
c. ADP is present and the intracellular acetylcholine level is high.
d. ATP is present and the intracellular Ca²⁺ concentration is high.

Guida verificata passo dopo passo
1
Understand the role of ATP in muscle contraction: ATP is crucial for the detachment of myosin heads from actin filaments, allowing the cycle of muscle contraction to continue.
Recognize the importance of calcium ions (Ca2+) in muscle contraction: High intracellular Ca2+ concentration leads to the binding of Ca2+ to troponin, which causes a conformational change that moves tropomyosin away from the binding sites on actin, allowing myosin to bind to actin.
Identify the role of troponin and tropomyosin: Troponin binds to Ca2+, which then causes tropomyosin to shift and expose the binding sites on actin for myosin attachment.
Consider the conditions required for continuous movement of myosin along actin: ATP must be present to provide energy for the myosin head to detach and reattach, and Ca2+ must be present to ensure that the binding sites on actin are exposed.
Evaluate the options given in the problem: The correct condition for myosin to continue moving along actin is when ATP is present and the intracellular Ca2+ concentration is high, as this allows the cycle of muscle contraction to proceed.

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ATP and Muscle Contraction

ATP is crucial for muscle contraction as it provides the energy needed for myosin heads to detach from actin filaments and re-cock for another cycle of movement. Without ATP, myosin remains bound to actin, preventing further contraction cycles. Thus, ATP presence is essential for continuous muscle contraction.
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Role of Calcium Ions (Ca2+) in Muscle Contraction

Calcium ions play a pivotal role in muscle contraction by binding to troponin, which causes a conformational change that moves tropomyosin away from actin's binding sites. This exposure allows myosin to bind to actin, facilitating contraction. High intracellular Ca2+ concentration is necessary for sustained muscle contraction.
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Troponin and Tropomyosin Regulation

Troponin and tropomyosin are regulatory proteins that control muscle contraction. Troponin binds to Ca2+, leading to tropomyosin's repositioning, which exposes actin's binding sites for myosin. This regulation ensures that muscle contraction occurs only when Ca2+ is present, preventing unwanted contractions.
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Cell Cycle Regulation