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In the context of principles of transmembrane transport, why does active transport require an input of energy (e.g., ATP hydrolysis or an ion gradient)?
A
Because it moves solutes down their electrochemical gradient, which always requires ATP to proceed.
B
Because it moves solutes against their electrochemical gradient, which is thermodynamically unfavorable without energy input.
C
Because it eliminates membrane selectivity by forming nonspecific pores that require ATP to remain open.
D
Because it allows solutes to diffuse directly through the lipid bilayer without any transport protein.
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1
Step 1: Understand the concept of electrochemical gradients, which combine both concentration gradients and electrical charge differences across a membrane, influencing the movement of solutes.
Step 2: Recognize that passive transport moves solutes down their electrochemical gradient, which is thermodynamically favorable and does not require energy input.
Step 3: Identify that active transport moves solutes against their electrochemical gradient, meaning from lower to higher concentration or against the electrical potential, which is thermodynamically unfavorable.
Step 4: Realize that because moving solutes against their gradient requires work, cells must provide energy, often through ATP hydrolysis or by coupling to another ion gradient, to drive this process.
Step 5: Conclude that active transport requires energy input to overcome the thermodynamic barrier of moving solutes against their electrochemical gradient, ensuring selective and regulated transport across membranes.