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In aerobic organisms, glycolysis converts one molecule of glucose into two molecules of pyruvate. What is the net gain produced directly by glycolysis per glucose molecule?
A
2 ATP and 2 FADH2
B
2 ATP and 6 NADH
C
2 ATP and 2 NADH
D
4 ATP and 2 NADH
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1
Recall that glycolysis is the metabolic pathway that breaks down one molecule of glucose (6 carbons) into two molecules of pyruvate (3 carbons each).
Identify the energy carriers produced during glycolysis: ATP and NADH are generated directly in this process.
Understand that glycolysis consumes 2 ATP molecules in its initial steps but produces 4 ATP molecules later, resulting in a net gain of ATP. Calculate the net ATP by subtracting ATP used from ATP produced.
Note that glycolysis also produces NADH by reducing NAD+ during the oxidation of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. Count how many NADH molecules are produced per glucose molecule.
Summarize the net products of glycolysis per glucose molecule: net ATP and net NADH, and confirm that FADH2 is not produced during glycolysis.