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What is the name of the enzyme that cleaves the miRNA in the nucleus before it travels to the cytoplasm to exert its effects?
A
RISC
B
Argonaut
C
DROSHA
D
RNA Polymerase
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Guida verificata passo dopo passo
1
Understand the role of miRNA (microRNA) in gene regulation, which involves processing steps in both the nucleus and the cytoplasm.
Recognize that miRNA is initially transcribed as a primary miRNA (pri-miRNA) in the nucleus.
Identify that the pri-miRNA needs to be processed into a precursor miRNA (pre-miRNA) before it can be exported to the cytoplasm.
Learn that the enzyme responsible for cleaving the pri-miRNA into pre-miRNA in the nucleus is called DROSHA.
Note that DROSHA is part of a microprocessor complex that includes other proteins, and this processing is crucial for the miRNA to eventually form a mature miRNA in the cytoplasm.