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In the DNA double helix, what primarily holds the two antiparallel strands together?
A
Covalent phosphodiester bonds between nucleotides on opposite strands
B
Ionic bonds between the phosphate groups and deoxyribose sugars across the helix
C
Peptide bonds formed between adjacent base pairs along the helix
D
Hydrogen bonds between complementary nitrogenous bases (A with T, and G with C)
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1
Understand the structure of DNA: DNA is composed of two antiparallel strands forming a double helix.
Identify the backbone of each strand: Each strand has a sugar-phosphate backbone connected by covalent phosphodiester bonds between nucleotides on the same strand.
Recognize that the two strands are held together not by covalent bonds between strands, but by interactions between nitrogenous bases.
Recall that complementary base pairing occurs between adenine (A) and thymine (T), and between guanine (G) and cytosine (C).
Know that these complementary bases are connected across the two strands by hydrogen bonds, which stabilize the double helix structure.