Domanda del libro di testo
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicing via splicing enhancers or splicing silencers.
437
views
Ch. 18 - Post-transcriptional Regulation in Eukaryotes
Klug12th EditionConcepts of GeneticsISBN: 9780135564776
Non è quello che usi tu?Cambia libro di testoScegli un libro di testo diverso
TOC.tableOfContents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Klug12th EditionConcepts of GeneticsISBN: 9780135564776Non è quello che usi tu?Cambia libro di testo
Tutti i libri di testo
Klug 12th EditionCh. 18 - Post-transcriptional Regulation in EukaryotesProblema 7
Klug 12th EditionCh. 18 - Post-transcriptional Regulation in EukaryotesProblema 7Capitolo 18, Problema 7
The regulation of mRNA decay relies heavily upon deadenylases and decapping enzymes. Explain how these classes of enzymes are critical to initiating mRNA decay.
Guida verificata passo dopo passo1
Begin by understanding that mRNA decay is a crucial process for regulating gene expression by controlling the lifespan of mRNA molecules in the cell.
Explain that deadenylases are enzymes that shorten the poly(A) tail at the 3' end of the mRNA, which is a key initial step in mRNA decay because the poly(A) tail protects mRNA from degradation and aids in translation.
Describe how the shortening of the poly(A) tail by deadenylases reduces mRNA stability, making the mRNA more susceptible to further degradation processes.
Introduce decapping enzymes, which remove the 5' cap structure of the mRNA; this cap normally protects mRNA from exonucleases and is essential for translation initiation.
Clarify that once the 5' cap is removed by decapping enzymes, the mRNA is exposed to 5' to 3' exonucleases, leading to rapid degradation of the mRNA molecule, thus effectively initiating mRNA decay.
Risposta video verificata per un problema simile:
Questa soluzione video è stata consigliata dai nostri tutor come utile per risolvere questo problema.
Durata del video:
2mConcetti chiave
Ecco i concetti essenziali che devi comprendere per rispondere correttamente alla domanda.
mRNA Decay Pathways
mRNA decay is a cellular process that controls gene expression by degrading messenger RNA molecules. It ensures that mRNAs do not persist longer than needed, allowing cells to regulate protein synthesis dynamically. The decay process typically begins with shortening of the poly(A) tail, followed by removal of the 5' cap, leading to exonucleolytic degradation.
Video consigliato:
Percorso guidato
05:44
Repair Pathways
Role of Deadenylases
Deadenylases are enzymes that shorten the poly(A) tail at the 3' end of mRNA. This deadenylation is often the first and rate-limiting step in mRNA decay, destabilizing the mRNA and making it more susceptible to further degradation. By removing the poly(A) tail, deadenylases trigger downstream decay mechanisms.
Video consigliato:
Function of Decapping Enzymes
Decapping enzymes remove the 5' cap structure of mRNA, which protects the transcript from exonucleases. Once the cap is removed, the mRNA becomes vulnerable to 5' to 3' exonucleolytic degradation. Decapping is a critical step that commits the mRNA to rapid decay, effectively terminating its translation potential.
Video consigliato:
Percorso guidato
08:26Functional Genomics
Pratica correlata
Domanda del libro di testo
Nonsense-mediated decay is an mRNA surveillance pathway that eliminates mRNAs with premature stop codons. How does the cell distinguish between normal mRNAs and those with a premature stop?
444
views
Domanda del libro di testo
AU-rich elements (AREs) are cis-elements in mRNAs that regulate stability and decay. How is it possible that a single mRNA sequence element can serve to stabilize an mRNA in some cases and lead to its decay in other scenarios?
622
views
Domanda del libro di testo
Explain how the use of alternative promoters and alternative polyadenylation signals produces mRNAs with different 5' and 3' ends.
778
views
Domanda del libro di testo
Consider the CT/CGRP example of alternative splicing show. Which different types of alternative splicing patterns are represented?
568
views
Domanda del libro di testo
What are processing bodies (P bodies), and what role do they play in mRNA regulation?
1241
views