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How can we ascertain the number of polygenes involved in the inheritance of a quantitative trait?
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Ch. 25 - Quantitative Genetics and Multifactorial Traits
Klug12th EditionConcepts of GeneticsISBN: 9780135564776
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Klug12th EditionConcepts of GeneticsISBN: 9780135564776Non è quello che usi tu?Cambia libro di testo
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Klug 12th EditionCh. 25 - Quantitative Genetics and Multifactorial TraitsProblema 1a
Klug 12th EditionCh. 25 - Quantitative Genetics and Multifactorial TraitsProblema 1aCapitolo 25, Problema 1a
How do we know that threshold traits are actually polygenic even though they may have as few as two discrete phenotypic classes?
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Understand the concept of threshold traits: Threshold traits are traits that exhibit discrete phenotypic classes (e.g., affected vs. unaffected) but are influenced by multiple genes and environmental factors. These traits are polygenic, meaning they are controlled by many genes, even though their phenotypic expression appears binary.
Recognize the role of liability: Liability is an underlying continuous variable that represents the combined genetic and environmental factors contributing to the trait. Individuals with liability above a certain threshold express one phenotype (e.g., affected), while those below the threshold express the other phenotype (e.g., unaffected).
Examine family studies and heritability: Threshold traits often show familial aggregation, meaning they are more common in families with affected individuals. This pattern suggests a genetic basis, as relatives share genetic factors that contribute to liability. Heritability studies further support the polygenic nature of these traits by quantifying the genetic contribution to liability.
Analyze population data: In populations, the distribution of liability typically follows a normal curve, consistent with the influence of multiple genes. The threshold for phenotypic expression divides this continuous distribution into discrete classes, reinforcing the idea that the trait is polygenic.
Consider genetic and environmental interactions: Threshold traits are influenced by both genetic and environmental factors. The interaction between these factors can shift an individual's liability, pushing them above or below the threshold. This complexity aligns with the polygenic model, where multiple genes and environmental inputs collectively determine the trait.
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Threshold Traits
Threshold traits are characteristics that exhibit a discrete phenotypic outcome, typically categorized into two or more classes, such as 'normal' and 'affected.' These traits are influenced by multiple genetic and environmental factors, meaning that an individual must reach a certain genetic threshold for the trait to manifest. This concept is crucial for understanding how complex traits can appear simple while being governed by underlying polygenic inheritance.
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Traits and Variance
Polygenic Inheritance
Polygenic inheritance refers to the phenomenon where multiple genes contribute to a single trait, resulting in a continuous range of phenotypes. In the case of threshold traits, even if only two phenotypic classes are observed, the underlying genetic architecture can involve many alleles across different loci. This complexity allows for variations in the expression of the trait, which can lead to the discrete classes seen in the phenotype.
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Genetic Threshold Model
The genetic threshold model posits that for a threshold trait to be expressed, an individual must possess a certain cumulative genetic liability that surpasses a specific threshold. This model explains why traits can appear to have discrete categories despite being influenced by many genes. It highlights the interaction between genetic predisposition and environmental factors, emphasizing that the expression of the trait is not solely determined by a single gene but rather by the combined effects of multiple genetic contributions.
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What findings led geneticists to postulate the multiple-factor hypothesis that invoked the idea of additive alleles to explain inheritance patterns?
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How do we assess environmental factors to determine if they impact the phenotype of a quantitatively inherited trait?
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